Table 4. Results of multivariate... | American Society of Hematology

Table 4.

Results of multivariate analysis using multiple imputation of missing values and double-robust adjustment for EFS and OS with allogeneic HCT in first CR or CRi used as a time-dependent variable in the full analysis set

	EFS			OS
Variable	HR	95% CI	P	HR	95% CI	P
AMLSG 16-10	0.62	0.52-0.73	<.001	0.66	0.55-0.80	<.001
Age (10-y increase)	1.15	1.08-1.23	<.001	1.31	1.21-1.41	<.001
Female	0.89	0.76-1.05	.161	0.88	0.74-1.05	.169
NPM1-mutated	0.48	0.41-0.57	<.001	0.77	0.64-0.92	.004
WBC (log10)	1.21	1.05-1.40	011	1.21	1.03-1.43	.021
BM blasts	0.91	0.60-1.39	0.672	1.16	0.73-1.86	.533
FLT3-ITD^high	1.25	1.02-1.53	.028	1.23	1.00-1.51	.050
HCT	0.55	0.44-0.70	<.001	0.58	0.47-0.72	0.001

	EFS			OS
Variable	HR	95% CI	P	HR	95% CI	P
AMLSG 16-10	0.62	0.52-0.73	<.001	0.66	0.55-0.80	<.001
Age (10-y increase)	1.15	1.08-1.23	<.001	1.31	1.21-1.41	<.001
Female	0.89	0.76-1.05	.161	0.88	0.74-1.05	.169
NPM1-mutated	0.48	0.41-0.57	<.001	0.77	0.64-0.92	.004
WBC (log10)	1.21	1.05-1.40	011	1.21	1.03-1.43	.021
BM blasts	0.91	0.60-1.39	0.672	1.16	0.73-1.86	.533
FLT3-ITD^high	1.25	1.02-1.53	.028	1.23	1.00-1.51	.050
HCT	0.55	0.44-0.70	<.001	0.58	0.47-0.72	0.001

BM, bone marrow.