Multivariate analysis: MRD values measured by RQ-PCR in BM as MRD kinetics
| . | TTP . | ||
|---|---|---|---|
| Variables . | HR . | 95% CI . | P value . |
| MIPI intermediate vs low | 0.68 | (0.241-1.99) | .5 |
| MIPI high vs low | 0.78 | (0.26-2.36) | .7 |
| Ki67 ≥30% | 2.27 | (0.92-5.61) | .075 |
| PR after ASCT | 4.74 | (1.02-21.9) | .046 |
| Alternating MRD after ASCT (vs persistently MRD NEG after ASCT, M6 and M12) | 5.51 | (2.02-15.0) | <.001 |
| Persistently MRD POS after ASCT (vs persistently MRD NEG after ASCT, M6 and M12) | 6.93 | (1.74-27.6) | .006 |
| . | TTP . | ||
|---|---|---|---|
| Variables . | HR . | 95% CI . | P value . |
| MIPI intermediate vs low | 0.68 | (0.241-1.99) | .5 |
| MIPI high vs low | 0.78 | (0.26-2.36) | .7 |
| Ki67 ≥30% | 2.27 | (0.92-5.61) | .075 |
| PR after ASCT | 4.74 | (1.02-21.9) | .046 |
| Alternating MRD after ASCT (vs persistently MRD NEG after ASCT, M6 and M12) | 5.51 | (2.02-15.0) | <.001 |
| Persistently MRD POS after ASCT (vs persistently MRD NEG after ASCT, M6 and M12) | 6.93 | (1.74-27.6) | .006 |
M6, 6 months from transplant; M12, 12 months from transplant; MRD NEG, negative minimal residual disease; MRD POS, positive minimal residual disease; PR, partial response.
78 randomized patients, landmark analysis starting from 12 months from transplant.