Multivariate analysis: MRD values measured by RQ-PCR in BM as a single “punctual” time point
| . | TTP . | ||
|---|---|---|---|
| Variables . | HR . | 95% CI . | P value . |
| MIPI intermediate vs low | 0.67 | (0.27-1.70) | .4 |
| MIPI high vs low | 0.81 | (0.27-2.41) | .7 |
| Ki67 ≥30% | 4.37 | (1.74-11.0) | .002 |
| PR after ASCT | 4.18 | (1.31-13.3) | .015 |
| MRD POS at M6 | 7.80 | (3.05-20.0) | <.001 |
| . | TTP . | ||
|---|---|---|---|
| Variables . | HR . | 95% CI . | P value . |
| MIPI intermediate vs low | 0.67 | (0.27-1.70) | .4 |
| MIPI high vs low | 0.81 | (0.27-2.41) | .7 |
| Ki67 ≥30% | 4.37 | (1.74-11.0) | .002 |
| PR after ASCT | 4.18 | (1.31-13.3) | .015 |
| MRD POS at M6 | 7.80 | (3.05-20.0) | <.001 |
M6, 6 months from transplant; MRD POS, positive minimal residual disease; PR, partial response.
84 randomized patients, landmark analysis starting from 6 months from transplant.