International Consensus Classification of mature lymphoid and histiocytic/dendritic cell neoplasms
| Mature B-cell neoplasms |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma |
| Monoclonal B-cell lymphocytosis |
| Chronic lymphocytic leukemia type |
| Non-chronic lymphocytic leukemia type |
| B-cell prolymphocytic leukemia |
| Splenic marginal zone lymphoma |
| Hairy cell leukemia |
| Splenic B-cell lymphoma/leukemia, unclassifiable |
| Splenic diffuse red pulp small B-cell lymphoma |
| Hairy cell leukemia-variant |
| Lymphoplasmacytic lymphoma |
| Waldenström macroglobulinemia |
| Immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (MGUS) |
| IgM MGUS, plasma cell type* |
| IgM MGUS, not otherwise specified (NOS)* |
| Primary cold agglutinin disease* |
| Heavy chain diseases |
| Mu heavy chain disease |
| Gamma heavy chain disease |
| Alpha heavy chain disease |
| Plasma cell neoplasms |
| Non-IgM MGUS |
| Multiple myeloma (plasma cell myeloma)* |
| Multiple myeloma, NOS |
| Multiple myeloma with recurrent genetic abnormality |
| Multiple myeloma with CCND family translocation |
| Multiple myeloma with MAF family translocation |
| Multiple myeloma with NSD2 translocation |
| Multiple myeloma with hyperdiploidy |
| Solitary plasmacytoma of bone |
| Extraosseous plasmacytoma |
| Monoclonal Ig deposition diseases |
| Ig light chain amyloidosis (AL)* |
| Localized AL amyloidosis* |
| Light chain and heavy chain deposition disease |
| Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) |
| Primary cutaneous marginal zone lymphoproliferative disorder* |
| Nodal marginal zone lymphoma |
| Pediatric nodal marginal zone lymphoma |
| Follicular lymphoma |
| In situ follicular neoplasia |
| Duodenal-type follicular lymphoma |
| BCL2-R–negative, CD23-positive follicle center lymphoma |
| Primary cutaneous follicle center lymphoma |
| Pediatric-type follicular lymphoma |
| Testicular follicular lymphoma* |
| Large B-cell lymphoma with IRF4 rearrangement* |
| Mantle cell lymphoma |
| In situ mantle cell neoplasia |
| Leukemic non-nodal mantle cell lymphoma |
| Diffuse large B-cell lymphoma, NOS |
| Germinal center B-cell subtype |
| Activated B-cell subtype |
| Large B-cell lymphoma with 11q aberration* |
| Nodular lymphocyte predominant B-cell lymphoma* |
| T cell/histiocyte-rich large B-cell lymphoma |
| Primary diffuse large B-cell lymphoma of the central nervous system |
| Primary diffuse large B-cell lymphoma of the testis* |
| Primary cutaneous diffuse large B-cell lymphoma, leg type |
| Intravascular large B-cell lymphoma |
| HHV-8 and Epstein-Barr virus–negative primary effusion-based lymphoma* |
| Epstein-Barr virus–positive mucocutaneous ulcer* |
| Epstein-Barr virus–positive diffuse large B-cell lymphoma, NOS |
| Diffuse large B-cell lymphoma associated with chronic inflammation |
| Fibrin-associated diffuse large B-cell lymphoma |
| Lymphomatoid granulomatosis |
| Epstein-Barr virus–positive polymorphic B-cell lymphoproliferative disorder, NOS* |
| ALK-positive large B-cell lymphoma |
| Plasmablastic lymphoma |
| HHV-8–associated lymphoproliferative disorders |
| Multicentric Castleman disease |
| HHV-8–positive germinotropic lymphoproliferative disorder |
| HHV-8–positive diffuse large B-cell lymphoma, NOS |
| Primary effusion lymphoma |
| Burkitt lymphoma |
| High-grade B-cell lymphoma, with MYC and BCL2 rearrangements* |
| High-grade B-cell lymphoma with MYC and BCL6 rearrangements* |
| High-grade B-cell lymphoma, NOS |
| Primary mediastinal large B-cell lymphoma |
| Mediastinal gray-zone lymphoma* |
| Classic Hodgkin lymphoma |
| Nodular sclerosis classic Hodgkin lymphoma |
| Lymphocyte-rich classic Hodgkin lymphoma |
| Mixed cellularity classic Hodgkin lymphoma |
| Lymphocyte-depleted classic Hodgkin lymphoma |
| Mature T-cell and NK-cell neoplasms |
| T-cell prolymphocytic leukemia |
| T-cell large granular lymphocytic leukemia |
| Chronic lymphoproliferative disorder of NK cells |
| Adult T-cell leukemia/lymphoma |
| Epstein-Barr virus–positive T-cell/NK-cell lymphoproliferative disorders of childhood* |
| Hydroa vacciniforme lymphoproliferative disorder |
| Classic |
| Systemic |
| Severe mosquito bite allergy |
| Chronic active Epstein-Barr virus disease, systemic (T-cell and NK-cell phenotype) |
| Systemic Epstein-Barr virus–positive T-cell lymphoma of childhood |
| Extranodal NK/T-cell lymphoma, nasal type |
| Aggressive NK-cell leukemia |
| Primary nodal Epstein-Barr virus–positive T-cell/NK-cell lymphoma* |
| Enteropathy-associated T-cell lymphoma |
| Type II refractory celiac disease* |
| Monomorphic epitheliotropic intestinal T-cell lymphoma |
| Intestinal T-cell lymphoma, NOS |
| Indolent clonal T-cell lymphoproliferative disorder of the gastrointestinal tract* |
| Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract* |
| Hepatosplenic T-cell lymphoma |
| Mycosis fungoides |
| Sézary syndrome |
| Primary cutaneous CD30+ T-cell lymphoproliferative disorders |
| Lymphomatoid papulosis |
| Primary cutaneous anaplastic large cell lymphoma |
| Primary cutaneous small/medium CD4+ T-cell lymphoproliferative disorder |
| Subcutaneous panniculitis-like T-cell lymphoma |
| Primary cutaneous gamma-delta T-cell lymphoma |
| Primary cutaneous acral CD8+ T-cell lymphoproliferative disorder* |
| Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma |
| Peripheral T-cell lymphoma, NOS |
| Follicular helper T-cell lymphoma* |
| Follicular helper T-cell lymphoma, angioimmunoblastic type (angioimmunoblastic T-cell lymphoma) |
| Follicular helper T-cell lymphoma, follicular type |
| Follicular helper T-cell lymphoma, NOS |
| Anaplastic large cell lymphoma, ALK positive |
| Anaplastic large cell lymphoma, ALK negative |
| Breast implant–associated anaplastic large cell lymphoma |
| Immunodeficiency-associated lymphoproliferative disorders |
| Posttransplant lymphoproliferative disorders |
| Nondestructive posttransplant lymphoproliferative disorders |
| Plasmacytic hyperplasia posttransplant lymphoproliferative disorder |
| Infectious mononucleosis posttransplant lymphoproliferative disorder |
| Florid follicular hyperplasia posttransplant lymphoproliferative disorder |
| Polymorphic posttransplant lymphoproliferative disorder |
| Monomorphic posttransplant lymphoproliferative disorder (B-cell and T-cell/NK-cell types)† |
| Classic Hodgkin lymphoma posttransplant lymphoproliferative disorder† |
| Other iatrogenic immunodeficiency-associated lymphoproliferative disorders |
| Histiocytic and dendritic cell neoplasms |
| Histiocytic sarcoma |
| Langerhans cell histiocytosis |
| Langerhans cell sarcoma |
| Indeterminate dendritic cell histiocytosis* |
| Interdigitating dendritic cell sarcoma* |
| ALK-positive histiocytosis* |
| Disseminated juvenile xanthogranuloma |
| Erdheim-Chester disease |
| Rosai-Dorfman-Destombes disease* |
| Follicular dendritic cell sarcoma |
| Fibroblastic reticular cell sarcoma* |
| Epstein-Barr virus–positive inflammatory follicular dendritic cell/fibroblastic reticular cell tumor* |
| Mature B-cell neoplasms |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma |
| Monoclonal B-cell lymphocytosis |
| Chronic lymphocytic leukemia type |
| Non-chronic lymphocytic leukemia type |
| B-cell prolymphocytic leukemia |
| Splenic marginal zone lymphoma |
| Hairy cell leukemia |
| Splenic B-cell lymphoma/leukemia, unclassifiable |
| Splenic diffuse red pulp small B-cell lymphoma |
| Hairy cell leukemia-variant |
| Lymphoplasmacytic lymphoma |
| Waldenström macroglobulinemia |
| Immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (MGUS) |
| IgM MGUS, plasma cell type* |
| IgM MGUS, not otherwise specified (NOS)* |
| Primary cold agglutinin disease* |
| Heavy chain diseases |
| Mu heavy chain disease |
| Gamma heavy chain disease |
| Alpha heavy chain disease |
| Plasma cell neoplasms |
| Non-IgM MGUS |
| Multiple myeloma (plasma cell myeloma)* |
| Multiple myeloma, NOS |
| Multiple myeloma with recurrent genetic abnormality |
| Multiple myeloma with CCND family translocation |
| Multiple myeloma with MAF family translocation |
| Multiple myeloma with NSD2 translocation |
| Multiple myeloma with hyperdiploidy |
| Solitary plasmacytoma of bone |
| Extraosseous plasmacytoma |
| Monoclonal Ig deposition diseases |
| Ig light chain amyloidosis (AL)* |
| Localized AL amyloidosis* |
| Light chain and heavy chain deposition disease |
| Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) |
| Primary cutaneous marginal zone lymphoproliferative disorder* |
| Nodal marginal zone lymphoma |
| Pediatric nodal marginal zone lymphoma |
| Follicular lymphoma |
| In situ follicular neoplasia |
| Duodenal-type follicular lymphoma |
| BCL2-R–negative, CD23-positive follicle center lymphoma |
| Primary cutaneous follicle center lymphoma |
| Pediatric-type follicular lymphoma |
| Testicular follicular lymphoma* |
| Large B-cell lymphoma with IRF4 rearrangement* |
| Mantle cell lymphoma |
| In situ mantle cell neoplasia |
| Leukemic non-nodal mantle cell lymphoma |
| Diffuse large B-cell lymphoma, NOS |
| Germinal center B-cell subtype |
| Activated B-cell subtype |
| Large B-cell lymphoma with 11q aberration* |
| Nodular lymphocyte predominant B-cell lymphoma* |
| T cell/histiocyte-rich large B-cell lymphoma |
| Primary diffuse large B-cell lymphoma of the central nervous system |
| Primary diffuse large B-cell lymphoma of the testis* |
| Primary cutaneous diffuse large B-cell lymphoma, leg type |
| Intravascular large B-cell lymphoma |
| HHV-8 and Epstein-Barr virus–negative primary effusion-based lymphoma* |
| Epstein-Barr virus–positive mucocutaneous ulcer* |
| Epstein-Barr virus–positive diffuse large B-cell lymphoma, NOS |
| Diffuse large B-cell lymphoma associated with chronic inflammation |
| Fibrin-associated diffuse large B-cell lymphoma |
| Lymphomatoid granulomatosis |
| Epstein-Barr virus–positive polymorphic B-cell lymphoproliferative disorder, NOS* |
| ALK-positive large B-cell lymphoma |
| Plasmablastic lymphoma |
| HHV-8–associated lymphoproliferative disorders |
| Multicentric Castleman disease |
| HHV-8–positive germinotropic lymphoproliferative disorder |
| HHV-8–positive diffuse large B-cell lymphoma, NOS |
| Primary effusion lymphoma |
| Burkitt lymphoma |
| High-grade B-cell lymphoma, with MYC and BCL2 rearrangements* |
| High-grade B-cell lymphoma with MYC and BCL6 rearrangements* |
| High-grade B-cell lymphoma, NOS |
| Primary mediastinal large B-cell lymphoma |
| Mediastinal gray-zone lymphoma* |
| Classic Hodgkin lymphoma |
| Nodular sclerosis classic Hodgkin lymphoma |
| Lymphocyte-rich classic Hodgkin lymphoma |
| Mixed cellularity classic Hodgkin lymphoma |
| Lymphocyte-depleted classic Hodgkin lymphoma |
| Mature T-cell and NK-cell neoplasms |
| T-cell prolymphocytic leukemia |
| T-cell large granular lymphocytic leukemia |
| Chronic lymphoproliferative disorder of NK cells |
| Adult T-cell leukemia/lymphoma |
| Epstein-Barr virus–positive T-cell/NK-cell lymphoproliferative disorders of childhood* |
| Hydroa vacciniforme lymphoproliferative disorder |
| Classic |
| Systemic |
| Severe mosquito bite allergy |
| Chronic active Epstein-Barr virus disease, systemic (T-cell and NK-cell phenotype) |
| Systemic Epstein-Barr virus–positive T-cell lymphoma of childhood |
| Extranodal NK/T-cell lymphoma, nasal type |
| Aggressive NK-cell leukemia |
| Primary nodal Epstein-Barr virus–positive T-cell/NK-cell lymphoma* |
| Enteropathy-associated T-cell lymphoma |
| Type II refractory celiac disease* |
| Monomorphic epitheliotropic intestinal T-cell lymphoma |
| Intestinal T-cell lymphoma, NOS |
| Indolent clonal T-cell lymphoproliferative disorder of the gastrointestinal tract* |
| Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract* |
| Hepatosplenic T-cell lymphoma |
| Mycosis fungoides |
| Sézary syndrome |
| Primary cutaneous CD30+ T-cell lymphoproliferative disorders |
| Lymphomatoid papulosis |
| Primary cutaneous anaplastic large cell lymphoma |
| Primary cutaneous small/medium CD4+ T-cell lymphoproliferative disorder |
| Subcutaneous panniculitis-like T-cell lymphoma |
| Primary cutaneous gamma-delta T-cell lymphoma |
| Primary cutaneous acral CD8+ T-cell lymphoproliferative disorder* |
| Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma |
| Peripheral T-cell lymphoma, NOS |
| Follicular helper T-cell lymphoma* |
| Follicular helper T-cell lymphoma, angioimmunoblastic type (angioimmunoblastic T-cell lymphoma) |
| Follicular helper T-cell lymphoma, follicular type |
| Follicular helper T-cell lymphoma, NOS |
| Anaplastic large cell lymphoma, ALK positive |
| Anaplastic large cell lymphoma, ALK negative |
| Breast implant–associated anaplastic large cell lymphoma |
| Immunodeficiency-associated lymphoproliferative disorders |
| Posttransplant lymphoproliferative disorders |
| Nondestructive posttransplant lymphoproliferative disorders |
| Plasmacytic hyperplasia posttransplant lymphoproliferative disorder |
| Infectious mononucleosis posttransplant lymphoproliferative disorder |
| Florid follicular hyperplasia posttransplant lymphoproliferative disorder |
| Polymorphic posttransplant lymphoproliferative disorder |
| Monomorphic posttransplant lymphoproliferative disorder (B-cell and T-cell/NK-cell types)† |
| Classic Hodgkin lymphoma posttransplant lymphoproliferative disorder† |
| Other iatrogenic immunodeficiency-associated lymphoproliferative disorders |
| Histiocytic and dendritic cell neoplasms |
| Histiocytic sarcoma |
| Langerhans cell histiocytosis |
| Langerhans cell sarcoma |
| Indeterminate dendritic cell histiocytosis* |
| Interdigitating dendritic cell sarcoma* |
| ALK-positive histiocytosis* |
| Disseminated juvenile xanthogranuloma |
| Erdheim-Chester disease |
| Rosai-Dorfman-Destombes disease* |
| Follicular dendritic cell sarcoma |
| Fibroblastic reticular cell sarcoma* |
| Epstein-Barr virus–positive inflammatory follicular dendritic cell/fibroblastic reticular cell tumor* |