Diagnostic qualifiers that should be used following a specific MDS, AML (or MDS/AML) diagnosis
| Therapy-related* • prior chemotherapy, radiotherapy, immune interventions |
| Progressing from MDS • MDS should be confirmed by standard diagnostics |
| Progressing from MDS/MPN (specify) • MDS/MPN should be confirmed by standard diagnostics |
| Germline predisposition |
| Therapy-related* • prior chemotherapy, radiotherapy, immune interventions |
| Progressing from MDS • MDS should be confirmed by standard diagnostics |
| Progressing from MDS/MPN (specify) • MDS/MPN should be confirmed by standard diagnostics |
| Germline predisposition |
Examples: AML with myelodysplasia-related cytogenetic abnormality, therapy-related; AML with myelodysplasia-related gene mutation, progressed from MDS; AML with myelodysplasia-related gene mutation, germline RUNX1 mutation.
Lymphoblastic leukemia/lymphoma may also be therapy-related, and that association should also be noted in the diagnosis.