Table 21.

Myeloid neoplasms with mutated TP53

TypeCytopeniaBlastsGenetics
MDS with mutated TP53 Any 0-9% bone marrow and blood blasts Multi-hit TP53 mutation* or TP53 mutation (VAF > 10%) and complex karyotype often with loss of 17p† 
MDS/AML with mutated TP53 Any 10-19% bone marrow or blood blasts Any somatic TP53 mutation (VAF > 10%) 
AML with mutated TP53 Not required ≥20% bone marrow or blood blasts or meets criteria for pure erythroid leukemia Any somatic TP53 mutation (VAF > 10%) 
TypeCytopeniaBlastsGenetics
MDS with mutated TP53 Any 0-9% bone marrow and blood blasts Multi-hit TP53 mutation* or TP53 mutation (VAF > 10%) and complex karyotype often with loss of 17p† 
MDS/AML with mutated TP53 Any 10-19% bone marrow or blood blasts Any somatic TP53 mutation (VAF > 10%) 
AML with mutated TP53 Not required ≥20% bone marrow or blood blasts or meets criteria for pure erythroid leukemia Any somatic TP53 mutation (VAF > 10%) 
*

Defined as 2 distinct TP53 mutations (each VAF > 10%) OR a single TP53 mutation with (1) 17p deletion on cytogenetics; (2) VAF of >50%; or (3) Copy-neutral LOH at the 17p TP53 locus.

†

If TP53 locus LOH information is not available.

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