Major ICC categories of myeloid neoplasms and acute leukemias
| MPNs |
| Chronic myeloid leukemia |
| Polycythemia vera |
| Essential thrombocythemia |
| Primary myelofibrosis |
| Early/prefibrotic primary myelofibrosis |
| Overt primary myelofibrosis |
| Chronic neutrophilic leukemia |
| Chronic eosinophilic leukemia, not otherwise specified |
| MPN, unclassifiable |
| Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions |
| Myeloid/lymphoid neoplasm with PDGFRA rearrangement |
| Myeloid/lymphoid neoplasm with PDGFRB rearrangement |
| Myeloid/lymphoid neoplasm with FGFR1 rearrangement |
| Myeloid/lymphoid neoplasm with JAK2 rearrangement |
| Myeloid/lymphoid neoplasm with FLT3 rearrangement |
| Myeloid/lymphoid neoplasm with ETV6::ABL1 |
| Mastocytosis |
| Myelodysplastic/myeloproliferative neoplasms |
| Chronic myelomonocytic leukemia |
| Clonal cytopenia with monocytosis of undetermined significance |
| Clonal monocytosis of undetermined significance |
| Atypical chronic myeloid leukemia |
| Myelodysplastic/myeloproliferative neoplasm with thrombocytosis and SF3B1 mutation |
| Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis, not otherwise specified |
| Myelodysplastic/myeloproliferative neoplasm, not otherwise specified |
| Premalignant clonal cytopenias and myelodysplastic syndromes |
| Clonal cytopenia of undetermined significance |
| Myelodysplastic syndrome with mutated SF3B1 |
| Myelodysplastic syndrome with del(5q) |
| Myelodysplastic syndrome with mutated TP53 |
| Myelodysplastic syndrome, not otherwise specified (MDS, NOS) |
| MDS, NOS without dysplasia |
| MDS, NOS with single lineage dysplasia |
| MDS, NOS with multilineage dysplasia |
| Myelodysplastic syndrome with excess blasts |
| Myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) |
| MDS/AML with mutated TP53 |
| MDS/AML with myelodysplasia-related gene mutations |
| MDS/AML with myelodysplasia-related cytogenetic abnormalities |
| MDS/AML, not otherwise specified |
| Pediatric and/or germline mutation-associated disorders |
| Juvenile myelomonocytic leukemia |
| Juvenile myelomonocytic leukemia-like neoplasms |
| Noonan syndrome-associated myeloproliferative disorder |
| Refractory cytopenia of childhood |
| Hematologic neoplasms with germline predisposition |
| Acute myeloid leukemias (Tables 25 and 26) |
| Myeloid proliferations associated with Down syndrome |
| Blastic plasmacytoid dendritic cell neoplasm |
| Acute leukemia of ambiguous lineage |
| Acute undifferentiated leukemia |
| Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR::ABL1 |
| MPAL, with t(v;11q23.3); KMT2A rearranged |
| MPAL, B/myeloid, NOS |
| MPAL, T/myeloid, NOS |
| B-lymphoblastic leukemia/lymphoma (Tables 27 and 28; supplemental Table 6) |
| T-lymphoblastic leukemia/lymphoma (Table 27; supplemental Table 6) |
| MPNs |
| Chronic myeloid leukemia |
| Polycythemia vera |
| Essential thrombocythemia |
| Primary myelofibrosis |
| Early/prefibrotic primary myelofibrosis |
| Overt primary myelofibrosis |
| Chronic neutrophilic leukemia |
| Chronic eosinophilic leukemia, not otherwise specified |
| MPN, unclassifiable |
| Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions |
| Myeloid/lymphoid neoplasm with PDGFRA rearrangement |
| Myeloid/lymphoid neoplasm with PDGFRB rearrangement |
| Myeloid/lymphoid neoplasm with FGFR1 rearrangement |
| Myeloid/lymphoid neoplasm with JAK2 rearrangement |
| Myeloid/lymphoid neoplasm with FLT3 rearrangement |
| Myeloid/lymphoid neoplasm with ETV6::ABL1 |
| Mastocytosis |
| Myelodysplastic/myeloproliferative neoplasms |
| Chronic myelomonocytic leukemia |
| Clonal cytopenia with monocytosis of undetermined significance |
| Clonal monocytosis of undetermined significance |
| Atypical chronic myeloid leukemia |
| Myelodysplastic/myeloproliferative neoplasm with thrombocytosis and SF3B1 mutation |
| Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis, not otherwise specified |
| Myelodysplastic/myeloproliferative neoplasm, not otherwise specified |
| Premalignant clonal cytopenias and myelodysplastic syndromes |
| Clonal cytopenia of undetermined significance |
| Myelodysplastic syndrome with mutated SF3B1 |
| Myelodysplastic syndrome with del(5q) |
| Myelodysplastic syndrome with mutated TP53 |
| Myelodysplastic syndrome, not otherwise specified (MDS, NOS) |
| MDS, NOS without dysplasia |
| MDS, NOS with single lineage dysplasia |
| MDS, NOS with multilineage dysplasia |
| Myelodysplastic syndrome with excess blasts |
| Myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) |
| MDS/AML with mutated TP53 |
| MDS/AML with myelodysplasia-related gene mutations |
| MDS/AML with myelodysplasia-related cytogenetic abnormalities |
| MDS/AML, not otherwise specified |
| Pediatric and/or germline mutation-associated disorders |
| Juvenile myelomonocytic leukemia |
| Juvenile myelomonocytic leukemia-like neoplasms |
| Noonan syndrome-associated myeloproliferative disorder |
| Refractory cytopenia of childhood |
| Hematologic neoplasms with germline predisposition |
| Acute myeloid leukemias (Tables 25 and 26) |
| Myeloid proliferations associated with Down syndrome |
| Blastic plasmacytoid dendritic cell neoplasm |
| Acute leukemia of ambiguous lineage |
| Acute undifferentiated leukemia |
| Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR::ABL1 |
| MPAL, with t(v;11q23.3); KMT2A rearranged |
| MPAL, B/myeloid, NOS |
| MPAL, T/myeloid, NOS |
| B-lymphoblastic leukemia/lymphoma (Tables 27 and 28; supplemental Table 6) |
| T-lymphoblastic leukemia/lymphoma (Table 27; supplemental Table 6) |