Table 3.

Crude and adjusted PFS, EFS, and OS comparisons between R-B and R-CHOP/R-DHAP

Variable(s) in the modelnPFSEFSOS
R-BR-CHOP/R-DHAPHR (95% CI)PHR (95% CI)PHR (95% CI)P
Unadjusted analyses 
 R-B vs R-CHOP/R-DHAP 97 232 0.87 (0.53-1.41) .56 0.88 (0.56-1.37) .57 0.81 (0.46-1.40) .44 
 MIPI continuous R-B 97 N/A 3.65 (1.94-6.85) <.001 3.26 (1.78-5.96) <.001 3.94 (2.0-7.76) <.001 
 MIPI continuous R-CHOP/R-DHAP N/A 232 1.78 (1.31-2.42) <.001 1.92 (1.46-2.52) <.001 2.33 (1.72-3.15) <.001 
 Blastoid/pleomorphic vs not R-B 97 N/A 4.16 (1.39-12.47) .011 3.5 (1.19-10.27) .023 3.75 (1.07-13.21) .039 
 Blastoid/pleomorphic vs not R-CHOP/R-DHAP N/A 169 1.63 (0.78-3.44) .196 1.72 (0.88-3.35) .110 1.73 (0.78-3.83) .174 
 Ki67 ≥ 30% vs < 30% R-B 89 N/A 2.08 (0.85-5.1) .110 2.6 (1.1-6.15) .029 2.27 (0.76-6.76) .143 
 Ki67 ≥ 30% vs < 30% R-CHOP/R-DHAP N/A 129 1.88 (1.03-3.44) .042 2.24 (1.31-3.83) .003 2.86 (1.55-5.29) .001 
 MCL35 high risk vs not R-B 50 N/A 2.42 (0.67-8.77) .180 2.14 (0.6-7.6) .240 6.65 (1.57-28.2) .010 
 MCL35 high risk vs not R-CHOP/R-DHAP N/A 36 20.5 (2.81-149) .003 21 (2.89-153) .003 20.5 (2.81-149) .003 
Adjusted analyses 
 R-B vs R-CHOP/R-DHAP 97 232 0.83 (0.51-1.34) .44 0.84 (0.54-1.31) .44 0.76 (0.44-1.32) .33 
 MIPI continuous 2.02 (1.54-2.64) <.001 2.08 (1.63-2.66) <.001 2.54 (1.93-3.34) <.001 
 R-B vs R-CHOP/R-DHAP 97 169 0.84 (0.51-1.39) .50 0.87 (0.55-1.38) .54 0.83 (0.47-1.48) .54 
 Blastoid/pleomorphic vs not 2.06 (1.11-3.81) .021 2.02 (1.14-3.56) .015 2.06 (1.06-4.02) .034 
 R-B vs R-CHOP/R-DHAP 89 129 0.83 (0.48-1.45) .51 0.78 (0.47-1.31) .34 0.63 (0.33-1.19) .15 
 Ki67 ≥ 30% vs < 30% 1.93 (1.17-3.17) .010 2.33 (1.49-3.66) <.001 2.72 (1.59-4.67) <.001 
 R-B vs R-CHOP/R-DHAP 89 169 0.82 (0.47-1.42) .47 0.81 (0.51-1.28) .36 0.69 (0.36-1.31) .26 
 MIPI continuous 2.33 (1.67-3.25) <.001 2.08 (1.58-2.74) <.001 2.88 (2.05-4.05) <.001 
 Blastoid/pleomorphic vs not 2.01 (1.04-3.90) .038 1.88 (1.06-3.32) .030 2.13 (1.05-4.30) .036 
 R-B vs R-CHOP/R-DHAP 89 129 0.76 (0.44-1.32) .33 0.78 (0.47-1.30) .33 0.63 (0.33-1.19) .15 
 MIPI continuous 2.18 (1.55-3.08) <.001 2.15 (1.59-2.90) <.001 2.53 (1.78-3.60) <.001 
 Ki67 ≥ 30% vs < 30% 1.46 (0.86-2.48) .16 1.91 (1.20-3.04) .006 1.95 (1.08-3.51) .026 
 R-B vs R-CHOP/R-DHAP 89 114 0.81 (0.47-1.42) .47 0.76 (0.45-1.28) .30 0.63 (0.33-1.21) .16 
 Ki67 ≥ 30% vs < 30% 1.73 (1.04-2.89) .035 2.09 (1.32-3.32) .002 2.51 (1.43-4.42) .001 
 Blastoid/pleomorphic vs not 2.01 (1.04-3.89) .039 1.92 (1.05-3.52) .035 2.05 (1.02-4.13) .045 
 R-B vs R-CHOP/R-DHAP 89 114 0.79 (0.45-1.37) .40 0.75 (0.45-1.25) .27 0.65 (0.34-1.24) .19 
 MIPI continuous 2.17 (1.53-3.07) <.001 2.14 (1.57-2.93) <.001 2.52 (1.76-3.60) <.001 
 Ki67 ≥ 30% vs < 30% 1.38 (0.81-2.36) .24 1.67 (1.03-2.71) .037 1.82 (1.0-3.31) .050 
 Blastoid/pleomorphic vs not 1.90 (0.98-3.71) .058 1.81 (0.98-3.34) .057 1.89 (0.93-3.84) .080 
Variable(s) in the modelnPFSEFSOS
R-BR-CHOP/R-DHAPHR (95% CI)PHR (95% CI)PHR (95% CI)P
Unadjusted analyses 
 R-B vs R-CHOP/R-DHAP 97 232 0.87 (0.53-1.41) .56 0.88 (0.56-1.37) .57 0.81 (0.46-1.40) .44 
 MIPI continuous R-B 97 N/A 3.65 (1.94-6.85) <.001 3.26 (1.78-5.96) <.001 3.94 (2.0-7.76) <.001 
 MIPI continuous R-CHOP/R-DHAP N/A 232 1.78 (1.31-2.42) <.001 1.92 (1.46-2.52) <.001 2.33 (1.72-3.15) <.001 
 Blastoid/pleomorphic vs not R-B 97 N/A 4.16 (1.39-12.47) .011 3.5 (1.19-10.27) .023 3.75 (1.07-13.21) .039 
 Blastoid/pleomorphic vs not R-CHOP/R-DHAP N/A 169 1.63 (0.78-3.44) .196 1.72 (0.88-3.35) .110 1.73 (0.78-3.83) .174 
 Ki67 ≥ 30% vs < 30% R-B 89 N/A 2.08 (0.85-5.1) .110 2.6 (1.1-6.15) .029 2.27 (0.76-6.76) .143 
 Ki67 ≥ 30% vs < 30% R-CHOP/R-DHAP N/A 129 1.88 (1.03-3.44) .042 2.24 (1.31-3.83) .003 2.86 (1.55-5.29) .001 
 MCL35 high risk vs not R-B 50 N/A 2.42 (0.67-8.77) .180 2.14 (0.6-7.6) .240 6.65 (1.57-28.2) .010 
 MCL35 high risk vs not R-CHOP/R-DHAP N/A 36 20.5 (2.81-149) .003 21 (2.89-153) .003 20.5 (2.81-149) .003 
Adjusted analyses 
 R-B vs R-CHOP/R-DHAP 97 232 0.83 (0.51-1.34) .44 0.84 (0.54-1.31) .44 0.76 (0.44-1.32) .33 
 MIPI continuous 2.02 (1.54-2.64) <.001 2.08 (1.63-2.66) <.001 2.54 (1.93-3.34) <.001 
 R-B vs R-CHOP/R-DHAP 97 169 0.84 (0.51-1.39) .50 0.87 (0.55-1.38) .54 0.83 (0.47-1.48) .54 
 Blastoid/pleomorphic vs not 2.06 (1.11-3.81) .021 2.02 (1.14-3.56) .015 2.06 (1.06-4.02) .034 
 R-B vs R-CHOP/R-DHAP 89 129 0.83 (0.48-1.45) .51 0.78 (0.47-1.31) .34 0.63 (0.33-1.19) .15 
 Ki67 ≥ 30% vs < 30% 1.93 (1.17-3.17) .010 2.33 (1.49-3.66) <.001 2.72 (1.59-4.67) <.001 
 R-B vs R-CHOP/R-DHAP 89 169 0.82 (0.47-1.42) .47 0.81 (0.51-1.28) .36 0.69 (0.36-1.31) .26 
 MIPI continuous 2.33 (1.67-3.25) <.001 2.08 (1.58-2.74) <.001 2.88 (2.05-4.05) <.001 
 Blastoid/pleomorphic vs not 2.01 (1.04-3.90) .038 1.88 (1.06-3.32) .030 2.13 (1.05-4.30) .036 
 R-B vs R-CHOP/R-DHAP 89 129 0.76 (0.44-1.32) .33 0.78 (0.47-1.30) .33 0.63 (0.33-1.19) .15 
 MIPI continuous 2.18 (1.55-3.08) <.001 2.15 (1.59-2.90) <.001 2.53 (1.78-3.60) <.001 
 Ki67 ≥ 30% vs < 30% 1.46 (0.86-2.48) .16 1.91 (1.20-3.04) .006 1.95 (1.08-3.51) .026 
 R-B vs R-CHOP/R-DHAP 89 114 0.81 (0.47-1.42) .47 0.76 (0.45-1.28) .30 0.63 (0.33-1.21) .16 
 Ki67 ≥ 30% vs < 30% 1.73 (1.04-2.89) .035 2.09 (1.32-3.32) .002 2.51 (1.43-4.42) .001 
 Blastoid/pleomorphic vs not 2.01 (1.04-3.89) .039 1.92 (1.05-3.52) .035 2.05 (1.02-4.13) .045 
 R-B vs R-CHOP/R-DHAP 89 114 0.79 (0.45-1.37) .40 0.75 (0.45-1.25) .27 0.65 (0.34-1.24) .19 
 MIPI continuous 2.17 (1.53-3.07) <.001 2.14 (1.57-2.93) <.001 2.52 (1.76-3.60) <.001 
 Ki67 ≥ 30% vs < 30% 1.38 (0.81-2.36) .24 1.67 (1.03-2.71) .037 1.82 (1.0-3.31) .050 
 Blastoid/pleomorphic vs not 1.90 (0.98-3.71) .058 1.81 (0.98-3.34) .057 1.89 (0.93-3.84) .080 

N/A, not applicable.

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