Characteristics of anti-VWF alloimmune reactions
| Anti-VWF alloantibodies in VWD; prevalence 5-10% in severe disease |
| Almost always in Type 3 VWD |
| Early reports showed an association with VWF null mutations |
| Polyclonal epitope responses with a report of similar familial epitope profiles |
| All IgG subclasses but IgG4 predominant |
| Some anti-VWF antibodies show precipitating activity |
| At high titers, some anti-VWF antibodies are associated with anaphylactic/anaphylactoid responses to VWF infusion |
| Very rare reports of immune tolerance attempts |
| Anti-VWF alloantibodies in VWD; prevalence 5-10% in severe disease |
| Almost always in Type 3 VWD |
| Early reports showed an association with VWF null mutations |
| Polyclonal epitope responses with a report of similar familial epitope profiles |
| All IgG subclasses but IgG4 predominant |
| Some anti-VWF antibodies show precipitating activity |
| At high titers, some anti-VWF antibodies are associated with anaphylactic/anaphylactoid responses to VWF infusion |
| Very rare reports of immune tolerance attempts |