Analysis of probability that specific coinherited HLA allele will be immunodominant
| Allele . | Lines expressing an allele coinherited by other alleles in the table . | Lines in which allele is dominant . | Estimated probability of dominance relative to other alleles . | 95% Confidence interval . | P value from binomial test P = 0.5 . |
|---|---|---|---|---|---|
| A 0201 | 50 | 37 | 0.74 | 0.60, 0.85 | <.001 |
| B0702 | 33 | 33 | 1.00 | 0.89, 1.00 | <.001 |
| A0101 | 18 | 3 | 0.17 | 0.04, 0.41 | .008 |
| A1101 | 12 | 1 | 0.08 | 0.00, 0.38 | .006 |
| A2402 | 14 | 3 | 0.21 | 0.05, 0.51 | .06 |
| A2601 | 8 | 4 | 0.50 | 0.16, 0.84 | 1.0 |
| B0801 | 10 | 4 | 0.40 | 0.12, 0.74 | .75 |
| B3501-3 | 16 | 8 | 0.50 | 0.25, 0.75 | 1.0 |
| B4001-06 | 7 | 3 | 0.43 | 0.10, 0.82 | 1.0 |
| B4403 | 12 | 4 | 0.33 | 0.10, 0.65 | .39 |
| Allele . | Lines expressing an allele coinherited by other alleles in the table . | Lines in which allele is dominant . | Estimated probability of dominance relative to other alleles . | 95% Confidence interval . | P value from binomial test P = 0.5 . |
|---|---|---|---|---|---|
| A 0201 | 50 | 37 | 0.74 | 0.60, 0.85 | <.001 |
| B0702 | 33 | 33 | 1.00 | 0.89, 1.00 | <.001 |
| A0101 | 18 | 3 | 0.17 | 0.04, 0.41 | .008 |
| A1101 | 12 | 1 | 0.08 | 0.00, 0.38 | .006 |
| A2402 | 14 | 3 | 0.21 | 0.05, 0.51 | .06 |
| A2601 | 8 | 4 | 0.50 | 0.16, 0.84 | 1.0 |
| B0801 | 10 | 4 | 0.40 | 0.12, 0.74 | .75 |
| B3501-3 | 16 | 8 | 0.50 | 0.25, 0.75 | 1.0 |
| B4001-06 | 7 | 3 | 0.43 | 0.10, 0.82 | 1.0 |
| B4403 | 12 | 4 | 0.33 | 0.10, 0.65 | .39 |
Exact 95% binomial confidence intervals were used to infer the probability of dominance relative to other alleles. The P‐values were generated from an exact binomial test that the probability of dominance was equal to 0.5.