Rates of ICH in patients with primary brain cancer or brain metastases treated with or without anticoagulants
| Setting . | No. of studies . | No. of ICH/no. of patients treated . | Anticoagulant therapy . | No. of ICH/no. of patients not treated . | No anticoagulant therapy . | RR . | 95% CI . | P . | I2 . |
|---|---|---|---|---|---|---|---|---|---|
| Overall patients | 17 | 152/1072 | 11.5% (95% CI, 7.4-17.6) | 177/1824 | 6.0% (95% CI, 3.0-11.5) | 1.81 | 1.15-2.84 | .001 | 60.3% |
| Patients with PBC | 11 | 80/659 | 12.5% (95% CI, 8.0-18.8) | 50/1346 | 4.4% (95% CI, 2.5-7.7) | 2.58 | 1.59-4.19 | <.001 | 45.5% |
| Patients with MBC | 4 | 61/265 | 14.7% (95% CI, 4.4-39.2) | 81/301 | 15.4% (95% CI, 5.3-37.2) | 0.86 | 0.45-1.65 | .287 | 0% |
| Patients treated with DOACs vs LMWH | 5 | 12/172 | 8.3% (95% CI, 4.4-15.3) | 71/278 | 11.7% (95% CI, 2.9-37.0) | 0.44 | 0.25-0.79 | .007 | 0% |
| Patients treated with LMWH vs warfarin | 4 | 15/211 | 5.9% (95% CI, 1.5-20.5) | 8/198 | 5.4% (95% CI, 1.5-17.3) | 1.45 | 0.56-3.79 | .185 | 0% |
| Overall major ICH | 4 | 33/239 | 10.4% (95% CI, 4.0-24.5) | 47/734 | 3.4% (95% CI, 0.6-17.6) | 1.93 | 0.79-4.73 | .001 | 38.7% |
| Major ICH in patients with PBC | 3 | 9/135 | 6.3% (95% CI, 1.7-20.3) | 9/545 | 1.8% (95% CI, 0.9-3.4) | 3.75 | 1.6-4.5 | .003 | 0% |
| Setting . | No. of studies . | No. of ICH/no. of patients treated . | Anticoagulant therapy . | No. of ICH/no. of patients not treated . | No anticoagulant therapy . | RR . | 95% CI . | P . | I2 . |
|---|---|---|---|---|---|---|---|---|---|
| Overall patients | 17 | 152/1072 | 11.5% (95% CI, 7.4-17.6) | 177/1824 | 6.0% (95% CI, 3.0-11.5) | 1.81 | 1.15-2.84 | .001 | 60.3% |
| Patients with PBC | 11 | 80/659 | 12.5% (95% CI, 8.0-18.8) | 50/1346 | 4.4% (95% CI, 2.5-7.7) | 2.58 | 1.59-4.19 | <.001 | 45.5% |
| Patients with MBC | 4 | 61/265 | 14.7% (95% CI, 4.4-39.2) | 81/301 | 15.4% (95% CI, 5.3-37.2) | 0.86 | 0.45-1.65 | .287 | 0% |
| Patients treated with DOACs vs LMWH | 5 | 12/172 | 8.3% (95% CI, 4.4-15.3) | 71/278 | 11.7% (95% CI, 2.9-37.0) | 0.44 | 0.25-0.79 | .007 | 0% |
| Patients treated with LMWH vs warfarin | 4 | 15/211 | 5.9% (95% CI, 1.5-20.5) | 8/198 | 5.4% (95% CI, 1.5-17.3) | 1.45 | 0.56-3.79 | .185 | 0% |
| Overall major ICH | 4 | 33/239 | 10.4% (95% CI, 4.0-24.5) | 47/734 | 3.4% (95% CI, 0.6-17.6) | 1.93 | 0.79-4.73 | .001 | 38.7% |
| Major ICH in patients with PBC | 3 | 9/135 | 6.3% (95% CI, 1.7-20.3) | 9/545 | 1.8% (95% CI, 0.9-3.4) | 3.75 | 1.6-4.5 | .003 | 0% |
MBC, metastatic brain cancer; PBC, primary brain cancer.