Table 2.

Univariable and multivariable analysis for OS and RFS

NOSRFS
3-y (95% CI)HR (95% CI)*P*Adj HR (95% CI)†Adj P†3-y (95% CI)HR (95% CI)*P*Adj HR (95% CI)†Adj P†
Age, y            
 <40 65 0.61 (0.47, 0.72) Reference .044 Reference .023 0.49 (0.36, 0.61) Reference .085 Reference .12 
 ≥40 62 0.38 (0.25, 0.51) 1.66 (1.00, 2.74)  1.83 (1.08, 3.08)  0.35 (0.23, 0.48) 1.50 (0.94, 2.39)  1.50 (0.90, 2.50)  
Sex 
 M 77 0.52 (0.40, 0.63) Reference .78 Reference .50 0.45 (0.33, 0.56) Reference .69 Reference .26 
 F 50 0.47 (0.31, 0.61) 1.07 (0.65, 1.78)  1.19 (0.71, 2.01)  0.40 (0.25, 0.54) 1.10 (0.68, 1.76)  1.32 (0.81, 2.13)  
Cytogenetics            
 Good/intermediate 98 0.52 (0.41, 0.62) Reference .77 Reference .56 0.46 (0.35, 0.56) Reference .73 Reference .49 
 High 29 0.43 (0.23, 0.62) 1.09 (0.62, 1.92)  1.19 (0.66, 2.15)  0.31 (0.13, 0.50) 1.10 (0.64, 1.88)  1.21 (0.70, 2.10)  
Disease status at HCT 
 CR1 78 0.59 (0.46, 0.70) Reference <.001 Reference <.001 0.51 (0.38, 0.62) Reference .001 Reference <.001 
 CR2/3 49 0.35 (0.22, 0.49) 2.26 (1.38, 3.71)  2.54 (1.53, 4.20)  0.30 (0.17, 0.43) 2.08 (1.30, 3.31)  2.21 (1.38, 3.53)  
MRD            
 Negative 76 0.52 (0.39, 0.64) Reference .74 Reference .74 0.41 (0.28, 0.53) Reference .75 Reference .95 
 Positive 13 0.54 (0.25, 0.76) 0.86 (0.36, 2.08)  0.86 (0.34, 2.12)  0.46 (0.19, 0.70) 0.88 (0.39, 1.97)  0.97 (0.41, 2.29)  
Donor type 
 MSD 41 0.48 (0.32, 0.63) Reference .018 Reference .015 0.41 (0.25, 0.56) Reference .065 Reference .11 
 MUD 37 0.68 (0.49, 0.81) 0.53 (0.26, 1.07)  0.46 (0.22, 0.95)  0.61 (0.43, 0.75) 0.65 (0.34, 1.22)  0.64 (0.34, 1.21)  
 mMUD 17 0.29 (0.09, 0.53) 1.70 (0.84, 3.45)  1.74 (0.84, 3.61)  0.32 (0.11, 0.55) 1.54 (0.77, 3.08)  1.58 (0.78, 3.22)  
 Haplo/cord 32 0.41 (0.21, 0.60) 1.31 (0.69, 2.48)  1.22 (0.63, 2.36)  0.27 (0.11, 0.46) 1.36 (0.75, 2.47)  1.20 (0.65, 2.19)  
Conditioning            
 MAC 87 0.51 (0.39, 0.62) Reference .092 Reference .31 0.45 (0.33, 0.56) Reference .028 Reference .014 
 RIC/NMA 40 0.48 (0.32, 0.63) 1.54 (0.92, 2.59)  1.35 (0.75, 2.42)  0.39 (0.24, 0.54) 1.69 (1.05, 2.73)  1.84 (1.13, 2.98)  
KPS 
 80-100 102 0.56 (0.44, 0.65) Reference .023 Reference .051 0.46 (0.35, 0.56) Reference .14 Reference .24 
 ≤70 15 0.32 (0.11, 0.56) 2.16 (1.08, 4.30)  1.99 (1.00, 3.99)  0.32 (0.11, 0.56) 1.65 (0.84, 3.25)  1.51 (0.76, 2.99)  
Ph-like            
 Other B-cells 71 0.50 (0.37, 0.61) Reference .59 Reference .72 0.44 (0.32, 0.56) Reference .36 Reference .32 
 Ph-like fusions 56 0.51 (0.36, 0.64) 1.14 (0.69, 1.88)  1.10 (0.66, 1.82)  0.41 (0.27, 0.54) 1.24 (0.78, 1.98)  1.27 (0.80, 2.02)  
NOSRFS
3-y (95% CI)HR (95% CI)*P*Adj HR (95% CI)†Adj P†3-y (95% CI)HR (95% CI)*P*Adj HR (95% CI)†Adj P†
Age, y            
 <40 65 0.61 (0.47, 0.72) Reference .044 Reference .023 0.49 (0.36, 0.61) Reference .085 Reference .12 
 ≥40 62 0.38 (0.25, 0.51) 1.66 (1.00, 2.74)  1.83 (1.08, 3.08)  0.35 (0.23, 0.48) 1.50 (0.94, 2.39)  1.50 (0.90, 2.50)  
Sex 
 M 77 0.52 (0.40, 0.63) Reference .78 Reference .50 0.45 (0.33, 0.56) Reference .69 Reference .26 
 F 50 0.47 (0.31, 0.61) 1.07 (0.65, 1.78)  1.19 (0.71, 2.01)  0.40 (0.25, 0.54) 1.10 (0.68, 1.76)  1.32 (0.81, 2.13)  
Cytogenetics            
 Good/intermediate 98 0.52 (0.41, 0.62) Reference .77 Reference .56 0.46 (0.35, 0.56) Reference .73 Reference .49 
 High 29 0.43 (0.23, 0.62) 1.09 (0.62, 1.92)  1.19 (0.66, 2.15)  0.31 (0.13, 0.50) 1.10 (0.64, 1.88)  1.21 (0.70, 2.10)  
Disease status at HCT 
 CR1 78 0.59 (0.46, 0.70) Reference <.001 Reference <.001 0.51 (0.38, 0.62) Reference .001 Reference <.001 
 CR2/3 49 0.35 (0.22, 0.49) 2.26 (1.38, 3.71)  2.54 (1.53, 4.20)  0.30 (0.17, 0.43) 2.08 (1.30, 3.31)  2.21 (1.38, 3.53)  
MRD            
 Negative 76 0.52 (0.39, 0.64) Reference .74 Reference .74 0.41 (0.28, 0.53) Reference .75 Reference .95 
 Positive 13 0.54 (0.25, 0.76) 0.86 (0.36, 2.08)  0.86 (0.34, 2.12)  0.46 (0.19, 0.70) 0.88 (0.39, 1.97)  0.97 (0.41, 2.29)  
Donor type 
 MSD 41 0.48 (0.32, 0.63) Reference .018 Reference .015 0.41 (0.25, 0.56) Reference .065 Reference .11 
 MUD 37 0.68 (0.49, 0.81) 0.53 (0.26, 1.07)  0.46 (0.22, 0.95)  0.61 (0.43, 0.75) 0.65 (0.34, 1.22)  0.64 (0.34, 1.21)  
 mMUD 17 0.29 (0.09, 0.53) 1.70 (0.84, 3.45)  1.74 (0.84, 3.61)  0.32 (0.11, 0.55) 1.54 (0.77, 3.08)  1.58 (0.78, 3.22)  
 Haplo/cord 32 0.41 (0.21, 0.60) 1.31 (0.69, 2.48)  1.22 (0.63, 2.36)  0.27 (0.11, 0.46) 1.36 (0.75, 2.47)  1.20 (0.65, 2.19)  
Conditioning            
 MAC 87 0.51 (0.39, 0.62) Reference .092 Reference .31 0.45 (0.33, 0.56) Reference .028 Reference .014 
 RIC/NMA 40 0.48 (0.32, 0.63) 1.54 (0.92, 2.59)  1.35 (0.75, 2.42)  0.39 (0.24, 0.54) 1.69 (1.05, 2.73)  1.84 (1.13, 2.98)  
KPS 
 80-100 102 0.56 (0.44, 0.65) Reference .023 Reference .051 0.46 (0.35, 0.56) Reference .14 Reference .24 
 ≤70 15 0.32 (0.11, 0.56) 2.16 (1.08, 4.30)  1.99 (1.00, 3.99)  0.32 (0.11, 0.56) 1.65 (0.84, 3.25)  1.51 (0.76, 2.99)  
Ph-like            
 Other B-cells 71 0.50 (0.37, 0.61) Reference .59 Reference .72 0.44 (0.32, 0.56) Reference .36 Reference .32 
 Ph-like fusions 56 0.51 (0.36, 0.64) 1.14 (0.69, 1.88)  1.10 (0.66, 1.82)  0.41 (0.27, 0.54) 1.24 (0.78, 1.98)  1.27 (0.80, 2.02)  

Adj, adjusted; MAC, myeloablative conditioning; NMA, nonmyeloablative.

*

Univariate analysis and log-rank test.

†

Based on the multivariable Cox regression model adjusted for age, disease status, and KPS for OS. Disease status and conditioning regimen were adjusted for RFS.

View Large
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal