Table 3. Individual cases of IFD Patient... | American Society of Hematology

Table 3.

Individual cases of IFD

Patient	Age (y)	Sex	Lymphoma histology	Prior transplant	Product	CRS	Max grade CRS¹¹	Tocilizumab for CRS or ICANS	Number tocilizumab doses	ICANS	Max Grade ICANS (CTCAE)	Corticosteroids for CRS or ICANS	Disease progression	D+ relapse	Alive	D+ Death	Cause of death	IFI	Organism	Site	Proven / probable	D+ diagnosis	Leukopenia on D+ diagnosis
1	65	Male	tCLL	AUTO	Axi-cel	Yes	1	Yes	1	Yes	3	Yes	Yes	11	No	17	PD	Invasive pulmonary aspergillosis	Aspergillus, ssp	Pulmonary	Probable	13	WBC: 0.17 ANC: ∼0 ALC: ∼0
2	38	Female	DLBCL	AUTO	Axi-cel	Yes	2	Yes	4	Yes	3	Yes	No	—	Yes	—	—	C albicans empyema	C. albicans	Pleural	Proven	16	WBC: 10860 ANC: 980 ALC: 9560
3	38	Male	PMBCL	AUTO	Axi-cel	Yes	1	Yes	2	Yes	3	Yes	No	—	No	18	Septic shock	C tropicalis fungemia	C. tropicalis	Blood	Proven	17	WBC: 220 ANC: 0 ALC: 200
4	64	Male	DLBCL	AUTO	Axi-cel	Yes	2	Yes	2	No	0	No	Yes	459	Yes	—	—	PJP	P. jirovecii	Pulmonary	Proven	115	WBC: 2160 ANC: 1300 ALC: 240
5	64	Male	DLBCL	AUTO	Axi-cel	Yes	1	No	0	Yes	2	Yes	No	—	Yes	—	—	PJP	P. jirovecii	Pulmonary	Probable	443	WBC: 14610 ANC: 13500 ALC: 410
6	63	Male	DLBCL	AUTO	Axi-cel	Yes	1	Yes	3	Yes	3	Yes	No	—	Yes	—	—	PJP	P. jirovecii	Pulmonary	Probable	390	WBC: 4700 ANC: 2910 ALC: 1130
7	57	Male	DLBCL	AUTO	Axi-cel	0	0	No	0	No	0	No	Yes	10	No	10	PD	Rhizopus pulmonary infection	Rhizopus ssp.	Pulmonary	Probable	7	WBC: 1450 ANC: 1090 ALC: 130
8	65	Male	tCLL	No	Axi-cel	Yes	2	Yes	4	Yes	3	Yes	Yes	30	No	72	PD	Invasive pulmonary aspergillosis	A fumigatus	Pulmonary	Probable	35	WBC: 1510 ANC: 940 ALC: 110

Patient	Age (y)	Sex	Lymphoma histology	Prior transplant	Product	CRS	Max grade CRS¹¹	Tocilizumab for CRS or ICANS	Number tocilizumab doses	ICANS	Max Grade ICANS (CTCAE)	Corticosteroids for CRS or ICANS	Disease progression	D+ relapse	Alive	D+ Death	Cause of death	IFI	Organism	Site	Proven / probable	D+ diagnosis	Leukopenia on D+ diagnosis
1	65	Male	tCLL	AUTO	Axi-cel	Yes	1	Yes	1	Yes	3	Yes	Yes	11	No	17	PD	Invasive pulmonary aspergillosis	Aspergillus, ssp	Pulmonary	Probable	13	WBC: 0.17 ANC: ∼0 ALC: ∼0
2	38	Female	DLBCL	AUTO	Axi-cel	Yes	2	Yes	4	Yes	3	Yes	No	—	Yes	—	—	C albicans empyema	C. albicans	Pleural	Proven	16	WBC: 10860 ANC: 980 ALC: 9560
3	38	Male	PMBCL	AUTO	Axi-cel	Yes	1	Yes	2	Yes	3	Yes	No	—	No	18	Septic shock	C tropicalis fungemia	C. tropicalis	Blood	Proven	17	WBC: 220 ANC: 0 ALC: 200
4	64	Male	DLBCL	AUTO	Axi-cel	Yes	2	Yes	2	No	0	No	Yes	459	Yes	—	—	PJP	P. jirovecii	Pulmonary	Proven	115	WBC: 2160 ANC: 1300 ALC: 240
5	64	Male	DLBCL	AUTO	Axi-cel	Yes	1	No	0	Yes	2	Yes	No	—	Yes	—	—	PJP	P. jirovecii	Pulmonary	Probable	443	WBC: 14610 ANC: 13500 ALC: 410
6	63	Male	DLBCL	AUTO	Axi-cel	Yes	1	Yes	3	Yes	3	Yes	No	—	Yes	—	—	PJP	P. jirovecii	Pulmonary	Probable	390	WBC: 4700 ANC: 2910 ALC: 1130
7	57	Male	DLBCL	AUTO	Axi-cel	0	0	No	0	No	0	No	Yes	10	No	10	PD	Rhizopus pulmonary infection	Rhizopus ssp.	Pulmonary	Probable	7	WBC: 1450 ANC: 1090 ALC: 130
8	65	Male	tCLL	No	Axi-cel	Yes	2	Yes	4	Yes	3	Yes	Yes	30	No	72	PD	Invasive pulmonary aspergillosis	A fumigatus	Pulmonary	Probable	35	WBC: 1510 ANC: 940 ALC: 110

ALC, absolute lymphocyte count; AUTO, autologous Axi-cel, axicabtagene ciloleucel; DLBCL, diffuse large B-cell lymphoma; max, maximum; PD, progressive disease; PMBCL, primary mediastinal B-cell lymphoma; tCLL, transformed CLL; WBC, white blood cell.

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