Summary of ages and sexes of patients with HM with DDX41 CV, and VUS and controls
| Disease . | Germline DDX41 . | DDX41+ CV (reference) . | DDX41+ VUS . | P (a) . | DDX41− WT . | P (b) . |
|---|---|---|---|---|---|---|
| HM | n | 111 | 60 | 4307 | ||
| Median age (y, range) | 68 (37-90) | 63 (7-92) | .01* | 67 (18-100) | .35 | |
| Sex male/female (M%) | 82/29 (74%) | 37/23(62%) | .10 | 2154/2153 (50%) | <.0001**** | |
| AML | n | 66 | 18 | 1365 | ||
| Median age (y, range) | 69 (47-90) | 62 (7-84) | .02* | 64 (18-90) | .002** | |
| Sex male/female (M%) | 49/17 (71%) | 10/8 (56%) | .12 | 737/628 (54%) | .001** | |
| MDS | n | 28 | 12 | 1109 | ||
| Median age (y, range) | 72 (60-88) | 69 (50-92) | .49 | 74 (36-98) | 0.64 | |
| Sex male/female (M%) | 21/7 (75%) | 9/3 (75%) | >.99 | 555/554 (50%) | .009** | |
| MPN | n | 4 | 11 | 470 | ||
| Median age (y, range) | 59 (40-85) | 54 (7-85) | .64 | 66 (18-95) | .74 | |
| Sex male/female (M%) | 1/3 (25%) | 5/6 (45%) | .33 | 192/287 (40%) | .36 |
| Disease . | Germline DDX41 . | DDX41+ CV (reference) . | DDX41+ VUS . | P (a) . | DDX41− WT . | P (b) . |
|---|---|---|---|---|---|---|
| HM | n | 111 | 60 | 4307 | ||
| Median age (y, range) | 68 (37-90) | 63 (7-92) | .01* | 67 (18-100) | .35 | |
| Sex male/female (M%) | 82/29 (74%) | 37/23(62%) | .10 | 2154/2153 (50%) | <.0001**** | |
| AML | n | 66 | 18 | 1365 | ||
| Median age (y, range) | 69 (47-90) | 62 (7-84) | .02* | 64 (18-90) | .002** | |
| Sex male/female (M%) | 49/17 (71%) | 10/8 (56%) | .12 | 737/628 (54%) | .001** | |
| MDS | n | 28 | 12 | 1109 | ||
| Median age (y, range) | 72 (60-88) | 69 (50-92) | .49 | 74 (36-98) | 0.64 | |
| Sex male/female (M%) | 21/7 (75%) | 9/3 (75%) | >.99 | 555/554 (50%) | .009** | |
| MPN | n | 4 | 11 | 470 | ||
| Median age (y, range) | 59 (40-85) | 54 (7-85) | .64 | 66 (18-95) | .74 | |
| Sex male/female (M%) | 1/3 (25%) | 5/6 (45%) | .33 | 192/287 (40%) | .36 |
P value (a) applies to DDX41+ CV vs DDX41+ VUS, and P value (b) applies to DDX41+ CV vs DDX41− WT.
P < .05; **P < .01; ****P < .0001.