Comparison of changes in iron, hematologic, and erythropoietic parameters in 6- to 7-week-old Townes sickle mice treated with 60 mg/kg vamifeport twice daily for 6 weeks and 8- to 12-week-old β-thalassemia intermedia (th3/+) mice3 treated with 30 or 100 mg/kg vamifeport twice daily for 36 days

Selected outcomesTownes sickle miceTh3/+ β-thalassemia mice
ParameterMarkerCompared with controlResponse to vamifeportCompared with controlResponse to vamifeport
Iron
 		Serum High ↓ Similar ↓ 
Liver High ↔ High ↔ 
Liver incorporation High ↓ High ↓ 
Hematologic Mean corpuscular hemoglobin concentration Low ↓ Low ↑ 
Mean corpuscular hemoglobin High ↓ Low ↓ 
Mean corpuscular volume High ↓ Low ↓ 
Red blood cells Similar ↔ Low (slight) ↑ 
Hemoglobin Low ↔ Low ↑ 
Erythropoietic
 		Reticulocytes High ↔ High ↓ 
Splenic index High ↓ High ↓ 
Mature marrow erythrocytes Low ↔ Low ↑ 
Selected outcomesTownes sickle miceTh3/+ β-thalassemia mice
ParameterMarkerCompared with controlResponse to vamifeportCompared with controlResponse to vamifeport
Iron
 		Serum High ↓ Similar ↓ 
Liver High ↔ High ↔ 
Liver incorporation High ↓ High ↓ 
Hematologic Mean corpuscular hemoglobin concentration Low ↓ Low ↑ 
Mean corpuscular hemoglobin High ↓ Low ↓ 
Mean corpuscular volume High ↓ Low ↓ 
Red blood cells Similar ↔ Low (slight) ↑ 
Hemoglobin Low ↔ Low ↑ 
Erythropoietic
 		Reticulocytes High ↔ High ↓ 
Splenic index High ↓ High ↓ 
Mature marrow erythrocytes Low ↔ Low ↑ 

All mice were fed low-iron chow at the onset of treatment and received iron supplemented water in the 6-hour timeframe between vamifeport doses.

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