Clinical, morphologic, and IG clonality features of 45 cases with the diagnosis of PNMZL
| Case no. . | Age, y . | Sex . | Lymph node biopsy site . | Original diagnosis . | Overlapping features . | IG gene rearrangement studies . |
|---|---|---|---|---|---|---|
| 1 | 16 | M | Preauricular | PNMZL | Yes | Monoclonal |
| 2 | 20 | M | Parotid | PNMZL | Yes | Monoclonal |
| 3 | 18 | M | Cervical | PNMZL | No | Monoclonal |
| 4 | 12 | M | Submandibular | PNMZL | Yes | Monoclonal |
| 5 | 20 | F | Occiput | PNMZL | Yes | Monoclonal |
| 6 | 15 | M | Posterior cervical | PNMZL | Yes | Monoclonal |
| 8 | 14 | F | Cervical | PNMZL | No | Monoclonal |
| 9 | 23 | M | Submental | PNMZL | Yes | Monoclonal |
| 10 | 18 | M | Inguinal | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 11 | 12 | M | Right inguinal | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 12 | 15 | M | Scalp | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 13 | 23 | M | Cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 14 | 20 | F | Inguinal | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 15 | 20 | M | Submental | PNMZL | No | Monoclonal |
| 17 | 20 | M | Parotid | PNMZL | No | Monoclonal |
| 19 | 9 | M | Parotid | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 21 | 9 | M | Cervical | PNMZL | No | Monoclonal |
| 23 | 16 | M | Right cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 25 | 5 | M | Cervical | PNMZL | No | Monoclonal |
| 27 | 6 | M | Cervical | PNMZL | Yes | Monoclonal |
| 28 | 5 | M | Left inguinal | PNMZL | Yes | Monoclonal |
| 29 | 8 | M | Submandibular | PNMZL | No | Monoclonal |
| 31 | 16 | M | Parotid | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 34 | 18 | M | Left cervical | PNMZL | Yes | Monoclonal |
| 35 | 6 | M | Axilla | PNMZL | Yes | Monoclonal |
| 36 | 22 | M | Cervical | PNMZL | No | Monoclonal |
| 37 | 16 | M | Right inguinal | PNMZL | No | Monoclonal |
| 38 | 17 | M | Submental | PNMZL | Yes | Monoclonal |
| 39 | 22 | M | Submental/cervical | PNMZL | Yes | Monoclonal |
| 40 | 16 | M | Cervical | PNMZL | Yes | Monoclonal |
| 41 | 14 | M | Left cervical | PNMZL | Yes | Monoclonal* |
| 42 | 6 | M | Right cervical | PNMZL | Yes | Monoclonal |
| 43 | 23 | M | Supraclavicular | PNMZL | Yes | Monoclonal |
| 44 | 15 | M | Right inguinal | PNMZL | Yes | Monoclonal |
| 45 | 13 | M | Right cervical | PNMZL | No | Monoclonal |
| 46 | 19 | M | Cervical | PNMZL | Yes | Monoclonal |
| 47 | 17 | M | Left cervical | PNMZL | No | Monoclonal |
| 48 | 11 | M | Right postauricular | PNMZL | No | Monoclonal |
| 49 | 11 | M | Inguinal | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 50 | 28 | M | Cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 51 | 15 | F | Cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 52 | 16 | M | Cervical | Overlapping features of PNMZL and PTFL | Yes | Insufficient DNA quality |
| 54 | 15 | M | Cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 55 | 30 | M | Inguinal | PNMZL | No | Monoclonal |
| 58 | 14 | F | Right cervical | PNMZL | No | Monoclonal |
| Control 1 | 15 | M | Cervical | Atypical marginal zone hyperplasia | NA | Polyclonal |
| Control 2 | 13 | M | Cervical | Atypical marginal zone hyperplasia | NA | Polyclonal |
| Control 3 | 18 | M | Cervical | Atypical marginal zone hyperplasia | NA | Polyclonal |
| Control 5 | 7 | F | Cervical | Progressive transformation of germinal centers | NA | Polyclonal |
| Control 6 | 4 | F | Cervical | Atypical marginal zone hyperplasia | NA | Polyclonal |
| Case no. . | Age, y . | Sex . | Lymph node biopsy site . | Original diagnosis . | Overlapping features . | IG gene rearrangement studies . |
|---|---|---|---|---|---|---|
| 1 | 16 | M | Preauricular | PNMZL | Yes | Monoclonal |
| 2 | 20 | M | Parotid | PNMZL | Yes | Monoclonal |
| 3 | 18 | M | Cervical | PNMZL | No | Monoclonal |
| 4 | 12 | M | Submandibular | PNMZL | Yes | Monoclonal |
| 5 | 20 | F | Occiput | PNMZL | Yes | Monoclonal |
| 6 | 15 | M | Posterior cervical | PNMZL | Yes | Monoclonal |
| 8 | 14 | F | Cervical | PNMZL | No | Monoclonal |
| 9 | 23 | M | Submental | PNMZL | Yes | Monoclonal |
| 10 | 18 | M | Inguinal | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 11 | 12 | M | Right inguinal | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 12 | 15 | M | Scalp | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 13 | 23 | M | Cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 14 | 20 | F | Inguinal | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 15 | 20 | M | Submental | PNMZL | No | Monoclonal |
| 17 | 20 | M | Parotid | PNMZL | No | Monoclonal |
| 19 | 9 | M | Parotid | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 21 | 9 | M | Cervical | PNMZL | No | Monoclonal |
| 23 | 16 | M | Right cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 25 | 5 | M | Cervical | PNMZL | No | Monoclonal |
| 27 | 6 | M | Cervical | PNMZL | Yes | Monoclonal |
| 28 | 5 | M | Left inguinal | PNMZL | Yes | Monoclonal |
| 29 | 8 | M | Submandibular | PNMZL | No | Monoclonal |
| 31 | 16 | M | Parotid | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 34 | 18 | M | Left cervical | PNMZL | Yes | Monoclonal |
| 35 | 6 | M | Axilla | PNMZL | Yes | Monoclonal |
| 36 | 22 | M | Cervical | PNMZL | No | Monoclonal |
| 37 | 16 | M | Right inguinal | PNMZL | No | Monoclonal |
| 38 | 17 | M | Submental | PNMZL | Yes | Monoclonal |
| 39 | 22 | M | Submental/cervical | PNMZL | Yes | Monoclonal |
| 40 | 16 | M | Cervical | PNMZL | Yes | Monoclonal |
| 41 | 14 | M | Left cervical | PNMZL | Yes | Monoclonal* |
| 42 | 6 | M | Right cervical | PNMZL | Yes | Monoclonal |
| 43 | 23 | M | Supraclavicular | PNMZL | Yes | Monoclonal |
| 44 | 15 | M | Right inguinal | PNMZL | Yes | Monoclonal |
| 45 | 13 | M | Right cervical | PNMZL | No | Monoclonal |
| 46 | 19 | M | Cervical | PNMZL | Yes | Monoclonal |
| 47 | 17 | M | Left cervical | PNMZL | No | Monoclonal |
| 48 | 11 | M | Right postauricular | PNMZL | No | Monoclonal |
| 49 | 11 | M | Inguinal | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 50 | 28 | M | Cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 51 | 15 | F | Cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 52 | 16 | M | Cervical | Overlapping features of PNMZL and PTFL | Yes | Insufficient DNA quality |
| 54 | 15 | M | Cervical | Overlapping features of PNMZL and PTFL | Yes | Monoclonal |
| 55 | 30 | M | Inguinal | PNMZL | No | Monoclonal |
| 58 | 14 | F | Right cervical | PNMZL | No | Monoclonal |
| Control 1 | 15 | M | Cervical | Atypical marginal zone hyperplasia | NA | Polyclonal |
| Control 2 | 13 | M | Cervical | Atypical marginal zone hyperplasia | NA | Polyclonal |
| Control 3 | 18 | M | Cervical | Atypical marginal zone hyperplasia | NA | Polyclonal |
| Control 5 | 7 | F | Cervical | Progressive transformation of germinal centers | NA | Polyclonal |
| Control 6 | 4 | F | Cervical | Atypical marginal zone hyperplasia | NA | Polyclonal |
IG, immunoglobulin; M, male; F, female; LN, lymph node; NA, not applicable.
An IGK clone was detected and confirmed by using NGS-based analysis (data not shown).