The results for cost-effectiveness analysis of first vs second-line daratumumab by the GRIFFIN and CASSIOPEIA model, with the time horizon of 5 y, 10 y, and lifelong (starting at age 60)
| . | . | Costs . | US (USD) . | Incremental costs . | US (USD) . | Effectiveness (QALY) . | Incremental effectiveness (QALY) . | ICER . | US (USD/QALY) . |
|---|---|---|---|---|---|---|---|---|---|
| Japan (JPY) . | Japan (JPY) . | Japan (JPY/QALY) . | |||||||
| GRIFFIN model | |||||||||
| 5 y | D-RVd | 47 885 772 | 713 318 | 7 477 011 | 95 943 | 3.34 | 0.08 | 99 017 942 | 1 270 567 |
| RVd | 40 408 762 | 617 375 | 3.26 | ||||||
| 10 y | D-RVd | 64 479 793 | 956 037 | −6 807 776 | −110 548 | 5.43 | 0.25 | Dominant | Dominant |
| RVd | 71 287 569 | 1 066 585 | 5.18 | ||||||
| Lifelong | D-RVd | 75 722 495 | 1 119 648 | −18 275 811 | −277 352 | 8.17 | 1.19 | Dominant | Dominant |
| RVd | 93 998 306 | 1 397 000 | 6.99 | ||||||
| CASSIOPEIA model | |||||||||
| 5 y | D-VTd | 28 136 231 | 423 225 | 2 242 802 | 33 967 | 3.38 | 0.06 | 37 268 707 | 564 436 |
| VTd | 25 893 429 | 389 257 | 3.32 | ||||||
| 10 y | D-VTd | 43 600 310 | 673 919 | −5 871 631 | −72 984 | 5.67 | 0.25 | Dominant | Dominant |
| VTd | 49 471 941 | 746 903 | 5.42 | ||||||
| Lifelong | D-VTd | 57 756 308 | 898 611 | −11 062 629 | −139 203 | 8.90 | 1.00 | Dominant | Dominant |
| VTd | 68 818 937 | 1 037 814 | 7.90 |
| . | . | Costs . | US (USD) . | Incremental costs . | US (USD) . | Effectiveness (QALY) . | Incremental effectiveness (QALY) . | ICER . | US (USD/QALY) . |
|---|---|---|---|---|---|---|---|---|---|
| Japan (JPY) . | Japan (JPY) . | Japan (JPY/QALY) . | |||||||
| GRIFFIN model | |||||||||
| 5 y | D-RVd | 47 885 772 | 713 318 | 7 477 011 | 95 943 | 3.34 | 0.08 | 99 017 942 | 1 270 567 |
| RVd | 40 408 762 | 617 375 | 3.26 | ||||||
| 10 y | D-RVd | 64 479 793 | 956 037 | −6 807 776 | −110 548 | 5.43 | 0.25 | Dominant | Dominant |
| RVd | 71 287 569 | 1 066 585 | 5.18 | ||||||
| Lifelong | D-RVd | 75 722 495 | 1 119 648 | −18 275 811 | −277 352 | 8.17 | 1.19 | Dominant | Dominant |
| RVd | 93 998 306 | 1 397 000 | 6.99 | ||||||
| CASSIOPEIA model | |||||||||
| 5 y | D-VTd | 28 136 231 | 423 225 | 2 242 802 | 33 967 | 3.38 | 0.06 | 37 268 707 | 564 436 |
| VTd | 25 893 429 | 389 257 | 3.32 | ||||||
| 10 y | D-VTd | 43 600 310 | 673 919 | −5 871 631 | −72 984 | 5.67 | 0.25 | Dominant | Dominant |
| VTd | 49 471 941 | 746 903 | 5.42 | ||||||
| Lifelong | D-VTd | 57 756 308 | 898 611 | −11 062 629 | −139 203 | 8.90 | 1.00 | Dominant | Dominant |
| VTd | 68 818 937 | 1 037 814 | 7.90 |