Demographic and laboratory characteristics of 25 volunteer control subjects and 28 patients newly diagnosed with APL
| Characteristic . | Control (n = 25) . | Patients with APL (n = 28) . |
|---|---|---|
| Age, y | 58 (28-78) | 42 (18-66) |
| Sex (female/male) | 10/15 | 11/17 |
| BMI, kg/m2 | 22.63 (22.4-25.81) | 23.75 (22.1-25.83) |
| WBC count, ×109/L | 5.95 (4.73-7.91) | 6.18 (0.96-19.04)* |
| <4 × 109/L | – | 9 (32%) |
| 4-10 × 109/L | – | 16 (57%) |
| >4 × 109/L | – | 3 (11%) |
| PLT count, ×109/L | 242.51 (196.4-273.81) | 173.31 (20.67-345.9)* |
| Hemoglobin, g/L | 133.21 (115.23-157.14) | 126.11 (63.13-170) |
| Blast, BM% | – | 48.32 (10.02-91.24) |
| PT, s | 12.67 (11.5-14.2) | 12.05 (10.5-17.3)* |
| APTT, s | 28 (25-35.6) | 25.83 (19.8-33.4) |
| PTINR | 1.01 (0.85-1.21) | 1.09 (0.95-1.59) |
| Fibrinogen, g/L | 3 (2.5-3.8) | 2.1 (0.41-3.61)* |
| d-dimer, mg/L | 0.23 (0.15-0.32) | 3.25 (0.12-21.82)* |
| Physical signs of bleeding (yes/no)† | – | 10/18 |
| Characteristic . | Control (n = 25) . | Patients with APL (n = 28) . |
|---|---|---|
| Age, y | 58 (28-78) | 42 (18-66) |
| Sex (female/male) | 10/15 | 11/17 |
| BMI, kg/m2 | 22.63 (22.4-25.81) | 23.75 (22.1-25.83) |
| WBC count, ×109/L | 5.95 (4.73-7.91) | 6.18 (0.96-19.04)* |
| <4 × 109/L | – | 9 (32%) |
| 4-10 × 109/L | – | 16 (57%) |
| >4 × 109/L | – | 3 (11%) |
| PLT count, ×109/L | 242.51 (196.4-273.81) | 173.31 (20.67-345.9)* |
| Hemoglobin, g/L | 133.21 (115.23-157.14) | 126.11 (63.13-170) |
| Blast, BM% | – | 48.32 (10.02-91.24) |
| PT, s | 12.67 (11.5-14.2) | 12.05 (10.5-17.3)* |
| APTT, s | 28 (25-35.6) | 25.83 (19.8-33.4) |
| PTINR | 1.01 (0.85-1.21) | 1.09 (0.95-1.59) |
| Fibrinogen, g/L | 3 (2.5-3.8) | 2.1 (0.41-3.61)* |
| d-dimer, mg/L | 0.23 (0.15-0.32) | 3.25 (0.12-21.82)* |
| Physical signs of bleeding (yes/no)† | – | 10/18 |
Data are presented as n (%) or median values (25th and 75th percentiles).
APTT, activated partial thromboplastin time (normal range: 20-40 seconds); Blasts, promyelocytes + blasts; BMI, body mass index (normal range: 18.5-25 kg/m2); PLT, platelet; PT, prothrombin time (normal range: 10-15 seconds); WBC, white blood cell.
P < .05 vs the healthy control subjects.
Physical signs of bleeding include mucosal bleeding, hematuria, petechiae, spontaneous ecchymoses, melena, menorrhagia, and hematemesis.