New CHAP multivariable prediction model
| Component . | Original dataset . | Imputation dataset . | ||
|---|---|---|---|---|
| β-coefficient . | HR (95% CI) . | β-coefficient . | HR (95% CI) . | |
| Creatinine (per µmol/L increase) | 0.0017 | 1.002 (0.999-1.004) | 0.0017 | 1.002 (0.999-1.004) |
| Hemoglobin (per g/L increase) | −0.0127 | 0.987 (0.980-0.994) | −0.0125 | 0.987 (0.981-0.994) |
| Age (per year increase) | 0.0251 | 1.025 (1.011-1.04) | 0.0237 | 1.024 (1.01-1.038) |
| Antiplatelet agent | 0.8995 | 2.458 (1.47-4.112) | 0.8871 | 2.428 (1.457-4.047) |
| Component . | Original dataset . | Imputation dataset . | ||
|---|---|---|---|---|
| β-coefficient . | HR (95% CI) . | β-coefficient . | HR (95% CI) . | |
| Creatinine (per µmol/L increase) | 0.0017 | 1.002 (0.999-1.004) | 0.0017 | 1.002 (0.999-1.004) |
| Hemoglobin (per g/L increase) | −0.0127 | 0.987 (0.980-0.994) | −0.0125 | 0.987 (0.981-0.994) |
| Age (per year increase) | 0.0251 | 1.025 (1.011-1.04) | 0.0237 | 1.024 (1.01-1.038) |
| Antiplatelet agent | 0.8995 | 2.458 (1.47-4.112) | 0.8871 | 2.428 (1.457-4.047) |
Baseline hazard at 1 y = 0.02. Sample calculation in a 65-y-old patient receiving a concomitant antiplatelet agent with a creatinine level of 115 µmol/L and a hemoglobin level of 110 g/L: 0.02*exp(115*0.0017 + 110*(−0.0127) + 65*0.0251 + 1*0.8995) = 7.6% predicted risk of major bleeding at 1 y of extended anticoagulation.
HR, hazard ratio.