Table 3. Impact of chromosomal... | American Society of Hematology

Table 3.

Impact of chromosomal abnormalities among adult ALL patients according to the allo-HCT period: multivariate analyses

1990-1999			2000-2009			2010-2019
Covariates	HR	95% CI	Covariates	HR	95% CI	Covariates	HR	95% CI
Overall mortality			Overall mortality			Overall mortality
Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref
High-risk non-Ph†	0.87	0.55-1.37	High-risk non-Ph†	1.19	0.93-1.52	High-risk non-Ph†	1.52	1.20-1.93
Ph⁺	1.36	1.12-1.65	Ph⁺	1.02	0.92-1.14	Ph⁺	0.86	0.76-0.96
Death or relapse			Death or relapse			Death or relapse
Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref
High-risk non-Ph†	0.91	0.58-1.43	High-risk non-Ph†	1.23	0.97-1.57	High-risk non-Ph†	1.39	1.11-1.75
Ph+	1.37	1.12-1.67	Ph+	1.08	0.97-1.20	Ph+	0.94	0.84-1.05
RR			RR			RR
Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref
High-risk non-Ph†	1.23	0.64-2.36	High-risk non-Ph†	1.09	0.75-1.61	High-risk non-Ph†	1.50	1.10-2.05
Ph+	1.37	1.03-1.83	Ph⁺	0.98	0.84-1.16	Ph⁺	0.91	0.78-1.07
NRM			NRM			NRM
Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref
High-risk non-Ph†	0.59	0.26-1.35	High-risk non-Ph†	1.12	0.78-1.61	High-risk non-Ph†	0.97	0.67-1.40
Ph⁺	1.02	0.74-1.40	Ph⁺	1.11	0.95-1.29	Ph⁺	0.98	0.85-1.14

1990-1999			2000-2009			2010-2019
Covariates	HR	95% CI	Covariates	HR	95% CI	Covariates	HR	95% CI
Overall mortality			Overall mortality			Overall mortality
Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref
High-risk non-Ph†	0.87	0.55-1.37	High-risk non-Ph†	1.19	0.93-1.52	High-risk non-Ph†	1.52	1.20-1.93
Ph⁺	1.36	1.12-1.65	Ph⁺	1.02	0.92-1.14	Ph⁺	0.86	0.76-0.96
Death or relapse			Death or relapse			Death or relapse
Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref
High-risk non-Ph†	0.91	0.58-1.43	High-risk non-Ph†	1.23	0.97-1.57	High-risk non-Ph†	1.39	1.11-1.75
Ph+	1.37	1.12-1.67	Ph+	1.08	0.97-1.20	Ph+	0.94	0.84-1.05
RR			RR			RR
Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref
High-risk non-Ph†	1.23	0.64-2.36	High-risk non-Ph†	1.09	0.75-1.61	High-risk non-Ph†	1.50	1.10-2.05
Ph+	1.37	1.03-1.83	Ph⁺	0.98	0.84-1.16	Ph⁺	0.91	0.78-1.07
NRM			NRM			NRM
Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref	Standard non-Ph*	1	Ref
High-risk non-Ph†	0.59	0.26-1.35	High-risk non-Ph†	1.12	0.78-1.61	High-risk non-Ph†	0.97	0.67-1.40
Ph⁺	1.02	0.74-1.40	Ph⁺	1.11	0.95-1.29	Ph⁺	0.98	0.85-1.14

Covariates included in the multivariate analyses were karyotype (standard non-Ph, high-risk non-Ph, Ph), patient age, white blood cell at diagnosis, conditioning (myeloablative conditioning, RIC), donor (related, unrelated bone marrow, unrelated cord blood), and disease status (CR1, subsequent CR, non-CR).

HR, hazard ratio.

Non-Ph other than t(8;14), t(4;11), t(14;18), hypodiploidy.

†

t(8;14), t(4;11), t(14;18), hypodiploidy.

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