Adjusted OS and LFS according to disease status, age, donor source, and Ph status
| . | . | 5-y OS (%) . | 95% CI . | 5-y LFS (%) . | 95% CI . |
|---|---|---|---|---|---|
| CR1 | 1990-1999 | 48.2 | 43.6-53.1 | 45.0 | 40.6-50.0 |
| 2000-2009 | 58.3 | 55.9-60.8 | 54.7 | 52.3-57.3 | |
| 2010-2019 | 70.2 | 68.4-72.2 | 65.5 | 63.6-67.5 | |
| Subsequent CR | 1990-1999 | 25.6 | 19.5-33.4 | 24.6 | 18.7-32.4 |
| 2000-2009 | 32.5 | 27.9-38.0 | 29.2 | 24.7-34.5 | |
| 2010-2019 | 44.1 | 39.2-49.5 | 37.7 | 33.1-42.9 | |
| Non-CR | 1990-1999 | 10.0 | 6.8-14.9 | 9.5 | 6.4-14.2 |
| 2000-2009 | 13.8 | 11.4-16.8 | 12.9 | 10.5-15.8 | |
| 2010-2019 | 22.7 | 19.2-26.8 | 17.9 | 14.7-21.7 | |
| ≤1, <25 y* | 1990-1999 | 45.1 | 40.2-50.6 | 40.8 | 36.0-46.3 |
| 2000-2009 | 49.8 | 45.9-54.2 | 46.7 | 42.7-51.0 | |
| 2010-2019 | 62.3 | 58.2-66.7 | 56.4 | 52.2-60.8 | |
| ≤25, <55 y* | 1990-1999 | 38.2 | 33.8-43.0 | 37.0 | 32.7-41.8 |
| 2000-2009 | 48.4 | 46.0-50.9 | 45.0 | 42.6-47.6 | |
| 2010-2019 | 58.9 | 56.6-61.4 | 53.1 | 50.8-55.5 | |
| ≤55 y* | 1990-1999 | 54.1 | 32.7-89.4 | 56.1 | 34.0-92.5 |
| 2000-2009 | 31.6 | 26.7-37.4 | 27.4 | 22.7-33.1 | |
| 2010-2019 | 46.7 | 43.1-50.6 | 41.4 | 37.9-45.2 | |
| Related donor* | 1990-1999 | 37.9 | 33.7-42.6 | 34.9 | 30.8-39.6 |
| 2000-2009 | 46.1 | 42.9-49.4 | 43.0 | 33.9-46.4 | |
| 2010-2019 | 57.3 | 54.1-60.7 | 50.6 | 47.5-54.0 | |
| Unrelated BM or PB* | 1990-1999 | 37.4 | 32.2-43.3 | 36.4 | 31.3-42.4 |
| 2000-2009 | 47.8 | 44.8-50.9 | 44.3 | 41.3-47.5 | |
| 2010-2019 | 60.4 | 57.6-63.3 | 55.3 | 52.5-58.2 | |
| Unrelated CB* | 1990-1999 | 79.5 | 59.6-100 | 77.6 | 56.0-100 |
| 2000-2009 | 40.1 | 35.6-45.1 | 36.5 | 32.2-41.4 | |
| 2010-2019 | 54.3 | 51.0-57.9 | 48.2 | 44.8-51.8 | |
| Non-Ph† | 1990-1999 | 38.3 | 34.0-43.2 | 36.3 | 32.1-41.1 |
| 2000-2009 | 45.4 | 42.9-48.1 | 43.3 | 40.8-46.0 | |
| 2010-2019 | 55.1 | 52.7-57.6 | 49.7 | 47.4-52.2 | |
| Ph+† | 1990-1999 | 27.1 | 20.9-35.2 | 25.9 | 19.8-33.9 |
| 2000-2009 | 46.1 | 42.9-49.5 | 40.7 | 37.5-44.1 | |
| 2010-2019 | 62.9 | 60.2-65.8 | 56.2 | 53.4-59.1 |
| . | . | 5-y OS (%) . | 95% CI . | 5-y LFS (%) . | 95% CI . |
|---|---|---|---|---|---|
| CR1 | 1990-1999 | 48.2 | 43.6-53.1 | 45.0 | 40.6-50.0 |
| 2000-2009 | 58.3 | 55.9-60.8 | 54.7 | 52.3-57.3 | |
| 2010-2019 | 70.2 | 68.4-72.2 | 65.5 | 63.6-67.5 | |
| Subsequent CR | 1990-1999 | 25.6 | 19.5-33.4 | 24.6 | 18.7-32.4 |
| 2000-2009 | 32.5 | 27.9-38.0 | 29.2 | 24.7-34.5 | |
| 2010-2019 | 44.1 | 39.2-49.5 | 37.7 | 33.1-42.9 | |
| Non-CR | 1990-1999 | 10.0 | 6.8-14.9 | 9.5 | 6.4-14.2 |
| 2000-2009 | 13.8 | 11.4-16.8 | 12.9 | 10.5-15.8 | |
| 2010-2019 | 22.7 | 19.2-26.8 | 17.9 | 14.7-21.7 | |
| ≤1, <25 y* | 1990-1999 | 45.1 | 40.2-50.6 | 40.8 | 36.0-46.3 |
| 2000-2009 | 49.8 | 45.9-54.2 | 46.7 | 42.7-51.0 | |
| 2010-2019 | 62.3 | 58.2-66.7 | 56.4 | 52.2-60.8 | |
| ≤25, <55 y* | 1990-1999 | 38.2 | 33.8-43.0 | 37.0 | 32.7-41.8 |
| 2000-2009 | 48.4 | 46.0-50.9 | 45.0 | 42.6-47.6 | |
| 2010-2019 | 58.9 | 56.6-61.4 | 53.1 | 50.8-55.5 | |
| ≤55 y* | 1990-1999 | 54.1 | 32.7-89.4 | 56.1 | 34.0-92.5 |
| 2000-2009 | 31.6 | 26.7-37.4 | 27.4 | 22.7-33.1 | |
| 2010-2019 | 46.7 | 43.1-50.6 | 41.4 | 37.9-45.2 | |
| Related donor* | 1990-1999 | 37.9 | 33.7-42.6 | 34.9 | 30.8-39.6 |
| 2000-2009 | 46.1 | 42.9-49.4 | 43.0 | 33.9-46.4 | |
| 2010-2019 | 57.3 | 54.1-60.7 | 50.6 | 47.5-54.0 | |
| Unrelated BM or PB* | 1990-1999 | 37.4 | 32.2-43.3 | 36.4 | 31.3-42.4 |
| 2000-2009 | 47.8 | 44.8-50.9 | 44.3 | 41.3-47.5 | |
| 2010-2019 | 60.4 | 57.6-63.3 | 55.3 | 52.5-58.2 | |
| Unrelated CB* | 1990-1999 | 79.5 | 59.6-100 | 77.6 | 56.0-100 |
| 2000-2009 | 40.1 | 35.6-45.1 | 36.5 | 32.2-41.4 | |
| 2010-2019 | 54.3 | 51.0-57.9 | 48.2 | 44.8-51.8 | |
| Non-Ph† | 1990-1999 | 38.3 | 34.0-43.2 | 36.3 | 32.1-41.1 |
| 2000-2009 | 45.4 | 42.9-48.1 | 43.3 | 40.8-46.0 | |
| 2010-2019 | 55.1 | 52.7-57.6 | 49.7 | 47.4-52.2 | |
| Ph+† | 1990-1999 | 27.1 | 20.9-35.2 | 25.9 | 19.8-33.9 |
| 2000-2009 | 46.1 | 42.9-49.5 | 40.7 | 37.5-44.1 | |
| 2010-2019 | 62.9 | 60.2-65.8 | 56.2 | 53.4-59.1 |
Adjusted for age at allo-HCT, white blood cell at diagnosis, Ph chromosome, conditioning intensity, and donor source.
Adjusted for age at allo-HCT, white blood cell at diagnosis, Ph chromosome, conditioning intensity, donor source, and disease status at allo-HCT.
Adjusted for age at allo-HCT, white blood cell at diagnosis, conditioning intensity, donor source, and disease status at allo-HCT.