Multivariable analysis of covariates associated with hyperfiltration and age at eGFR decline to normal range in pooled cohorts with sickle cell anemia
| Variables . | Hyperfiltration . | Decline in eGFR to Normal Range . | ||||||
|---|---|---|---|---|---|---|---|---|
| CKD-EPI–2009 . | CKD-EPI–2021 . | CKD-EPI–2009 . | CKD-EPI–2021 . | |||||
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Age | 0.78 (0.73-0.83) | <.0001 | 0.75 (0.70-0.81) | <.0001 | — | — | — | — |
| Male | 0.32 (0.18-0.58) | .0002 | 0.24 (0.13-0.44) | <.0001 | 2.20 (1.26-3.87) | .006 | 3.39 (2.01-5.69) | <.0001 |
| Weight | 0.96 (0.94-0.99) | .001 | 0.97 (0.95-0.99) | .004 | — | — | — | — |
| Systolic blood pressure | — | — | — | — | 1.02 (1.01-1.04) | .01 | — | — |
| Use of hydroxyurea | — | — | — | — | 1.74 (1.002-3.03) | .05 | — | — |
| Variables . | Hyperfiltration . | Decline in eGFR to Normal Range . | ||||||
|---|---|---|---|---|---|---|---|---|
| CKD-EPI–2009 . | CKD-EPI–2021 . | CKD-EPI–2009 . | CKD-EPI–2021 . | |||||
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Age | 0.78 (0.73-0.83) | <.0001 | 0.75 (0.70-0.81) | <.0001 | — | — | — | — |
| Male | 0.32 (0.18-0.58) | .0002 | 0.24 (0.13-0.44) | <.0001 | 2.20 (1.26-3.87) | .006 | 3.39 (2.01-5.69) | <.0001 |
| Weight | 0.96 (0.94-0.99) | .001 | 0.97 (0.95-0.99) | .004 | — | — | — | — |
| Systolic blood pressure | — | — | — | — | 1.02 (1.01-1.04) | .01 | — | — |
| Use of hydroxyurea | — | — | — | — | 1.74 (1.002-3.03) | .05 | — | — |