CRS, ICANS, and adverse events after NS7CAR T-cell infusion*
| CRS/ICANS . | Grade 1 (n) . | Grade 2 (n) . | Grade 3 (n) . | Grade 4 (n) . |
|---|---|---|---|---|
| CRS | 14 | 4 | 1 | 0 |
| Fever (≥38°C) | 19 | |||
| Hypotension† | 0 | 4 | 0 | 0 |
| Hypoxia | 0 | 3 | 1 | 0 |
| ICANS | 2 | 0 | 0 | 0 |
| Decreased level of consciousness | 1 | 0 | 0 | 0 |
| Seizure | 0 | 0 | 0 | 0 |
| Impairment of motor functions | 1 | 0 | 0 | 0 |
| Elevated ICP or cerebral edema | 0 | 0 | 0 | 0 |
| CRS/ICANS . | Grade 1 (n) . | Grade 2 (n) . | Grade 3 (n) . | Grade 4 (n) . |
|---|---|---|---|---|
| CRS | 14 | 4 | 1 | 0 |
| Fever (≥38°C) | 19 | |||
| Hypotension† | 0 | 4 | 0 | 0 |
| Hypoxia | 0 | 3 | 1 | 0 |
| ICANS | 2 | 0 | 0 | 0 |
| Decreased level of consciousness | 1 | 0 | 0 | 0 |
| Seizure | 0 | 0 | 0 | 0 |
| Impairment of motor functions | 1 | 0 | 0 | 0 |
| Elevated ICP or cerebral edema | 0 | 0 | 0 | 0 |
| Adverse events . | Grade 1 (n) . | Grade 2 (n) . | Grade 3 (n) . | Grade 4 (n) . |
|---|---|---|---|---|
| Hematologic event | ||||
| Anemia | 0 | 2 | 17 | 1 |
| Neutropenia | 0 | 0 | 0 | 20 |
| Lymphopenia | 0 | 0 | 0 | 20 |
| Thrombocytopenia | 0 | 1 | 3 | 15 |
| Gastrointestinal event | ||||
| Loss of appetite | 8 | 8 | 0 | 0 |
| Nausea/vomiting/diarrhea | 6 | 2 | 0 | 0 |
| Abdominal bloating | 1 | 0 | 0 | 0 |
| Cardiovascular event | ||||
| Chest pain | 1 | 0 | 0 | 0 |
| Tachycardia | 10 | 2 | 1 | 0 |
| Heart failure | 1 | 0 | 0 | 0 |
| General conditions | ||||
| Fatigue | 4 | 6 | 1 | 0 |
| Flu-like symptom | 5 | 4 | 5 | 0 |
| Rash | 1 | 1 | 3 | 0 |
| Peripheral edema | 5 | 0 | 0 | 0 |
| Laboratory values | ||||
| AST increase | 2 | 5 | 3 | 2 |
| ALT increase | 3 | 1 | 5 | 2 |
| Bilirubin increase | 2 | 1 | 3 | 0 |
| Creatine increase | 1 | 1 | 0 | 0 |
| LDH increase | 19 | 0 | 0 | 0 |
| Infection | ||||
| Sepsis | 0 | 0 | 2 | 0 |
| Lung infection | 0 | 0 | 0 | 0 |
| Skin infection | 0 | 0 | 1 | 0 |
| Oral ulcer | 1 | 2 | 3 | 0 |
| CMV activation | 1 | 0 | 0 | 0 |
| Coagulopathy | 0 | 0 | 1 | 0 |
| Adverse events . | Grade 1 (n) . | Grade 2 (n) . | Grade 3 (n) . | Grade 4 (n) . |
|---|---|---|---|---|
| Hematologic event | ||||
| Anemia | 0 | 2 | 17 | 1 |
| Neutropenia | 0 | 0 | 0 | 20 |
| Lymphopenia | 0 | 0 | 0 | 20 |
| Thrombocytopenia | 0 | 1 | 3 | 15 |
| Gastrointestinal event | ||||
| Loss of appetite | 8 | 8 | 0 | 0 |
| Nausea/vomiting/diarrhea | 6 | 2 | 0 | 0 |
| Abdominal bloating | 1 | 0 | 0 | 0 |
| Cardiovascular event | ||||
| Chest pain | 1 | 0 | 0 | 0 |
| Tachycardia | 10 | 2 | 1 | 0 |
| Heart failure | 1 | 0 | 0 | 0 |
| General conditions | ||||
| Fatigue | 4 | 6 | 1 | 0 |
| Flu-like symptom | 5 | 4 | 5 | 0 |
| Rash | 1 | 1 | 3 | 0 |
| Peripheral edema | 5 | 0 | 0 | 0 |
| Laboratory values | ||||
| AST increase | 2 | 5 | 3 | 2 |
| ALT increase | 3 | 1 | 5 | 2 |
| Bilirubin increase | 2 | 1 | 3 | 0 |
| Creatine increase | 1 | 1 | 0 | 0 |
| LDH increase | 19 | 0 | 0 | 0 |
| Infection | ||||
| Sepsis | 0 | 0 | 2 | 0 |
| Lung infection | 0 | 0 | 0 | 0 |
| Skin infection | 0 | 0 | 1 | 0 |
| Oral ulcer | 1 | 2 | 3 | 0 |
| CMV activation | 1 | 0 | 0 | 0 |
| Coagulopathy | 0 | 0 | 1 | 0 |