Table 1. Patient characteristics at... | American Society of Hematology

Table 1.

Patient characteristics at baseline and response after NS7CAR T-cell infusion

Patient no.	Age (y)	Sex (F/M)	Diagnosis	History of prior HSCT	PB blasts at enrollment (by morphology), %	BM blasts at enrollment (by FCM), %	EMD at enrollment	Source of CAR T cells	Dose infused (CAR T cells per kg)	BM & PB evaluation at day 28	Best EMD response	CRS	ICANS
Pt.01	37	F	T-LBL	Yes	0	0.00	Yes	Donor	0.5 × 10⁶	MRD(−) Cri	CR	1	0
Pt.02	3	M	T-ALL	No	0	1.17	No	Patient	1 × 10⁶	MRD(−) CR	—	0	0
Pt.03	14	M	T-ALL	No	0	0.18	Yes	Patient	1 × 10⁶	MRD(−) CR	CR	1	0
Pt.04	28	M	T-ALL	Yes	1	7.27	No	Patient	1 × 10⁶	MRD(−) CRi	—	1	0
Pt.05	30	M	T-ALL	Yes	4	33.72	No	Donor	1 × 10⁶	MRD(−) CRi	—	1	1
Pt.06	47	F	T-LBL	No	3	87.27	No*	Patient	1 × 10⁶	MRD(−) CRi	—	1	0
Pt.07	42	F	T-ALL	No	33	65.03	No	Patient	1 × 10⁶	MRD(−) CRi	—	1	0
Pt.08	15	F	T-ALL	No	4	15.78	No	Patient	1 × 10⁶	MRD(−) CR	—	1	0
Pt.09	25	M	T-LBL	No	0	0.00	Yes	Patient	1 × 10⁶	MRD(−) CRi	SD	1	0
Pt.10	19	M	T-ALL	No	62	60.23	Yes	Patient	1 × 10⁶	MRD(−) CR	CR	1	0
Pt.11	16	M	T-LBL	No	0	0.00	Yes	Patient	2 × 10⁶	MRD(−) CRi	PR	1	0
Pt.12	40	M	T-LBL	Yes	0	0.78	Yes	Patient	1 × 10⁶	MRD(−) CRi	CR	3	1
Pt.13	11	M	T-ALL	No	0	53.67	Yes	Patient	1.5 × 10⁶	NR	NR	2	0
Pt.14	7	M	T-ALL	No	0	46.37	No	Patient	1 × 10⁶	MRD(−) CRi	—	2	0
Pt.15	15	M	T-ALL	No	1	4.42	Yes	Patient	1 × 10⁶	MRD(−) CRi	CR	1	0
Pt.16	13	M	T-ALL	No	0	4.28	No	Patient	1 × 10⁶	MRD(−) CRi	—	2	0
Pt.17	21	F	T-ALL	No	0	56.01	No	Patient	0.5 × 10⁶	MRD(−) CRi	—	1	0
Pt.18	32	M	T-ALL	No	0	21.49	No	Patient	0.5 × 10⁶	MRD(−) CR	—	2	0
Pt.19	36	F	T-LBL	Yes	6	10.76	Yes	Patient	1 × 10⁶	MRD(−) CRi	PD	1	0
Pt.20	22	M	T-ALL	No	0	56.63	No	Patient	1 × 10⁶	MRD(−) CRi	—	1	0

Patient no.	Age (y)	Sex (F/M)	Diagnosis	History of prior HSCT	PB blasts at enrollment (by morphology), %	BM blasts at enrollment (by FCM), %	EMD at enrollment	Source of CAR T cells	Dose infused (CAR T cells per kg)	BM & PB evaluation at day 28	Best EMD response	CRS	ICANS
Pt.01	37	F	T-LBL	Yes	0	0.00	Yes	Donor	0.5 × 10⁶	MRD(−) Cri	CR	1	0
Pt.02	3	M	T-ALL	No	0	1.17	No	Patient	1 × 10⁶	MRD(−) CR	—	0	0
Pt.03	14	M	T-ALL	No	0	0.18	Yes	Patient	1 × 10⁶	MRD(−) CR	CR	1	0
Pt.04	28	M	T-ALL	Yes	1	7.27	No	Patient	1 × 10⁶	MRD(−) CRi	—	1	0
Pt.05	30	M	T-ALL	Yes	4	33.72	No	Donor	1 × 10⁶	MRD(−) CRi	—	1	1
Pt.06	47	F	T-LBL	No	3	87.27	No*	Patient	1 × 10⁶	MRD(−) CRi	—	1	0
Pt.07	42	F	T-ALL	No	33	65.03	No	Patient	1 × 10⁶	MRD(−) CRi	—	1	0
Pt.08	15	F	T-ALL	No	4	15.78	No	Patient	1 × 10⁶	MRD(−) CR	—	1	0
Pt.09	25	M	T-LBL	No	0	0.00	Yes	Patient	1 × 10⁶	MRD(−) CRi	SD	1	0
Pt.10	19	M	T-ALL	No	62	60.23	Yes	Patient	1 × 10⁶	MRD(−) CR	CR	1	0
Pt.11	16	M	T-LBL	No	0	0.00	Yes	Patient	2 × 10⁶	MRD(−) CRi	PR	1	0
Pt.12	40	M	T-LBL	Yes	0	0.78	Yes	Patient	1 × 10⁶	MRD(−) CRi	CR	3	1
Pt.13	11	M	T-ALL	No	0	53.67	Yes	Patient	1.5 × 10⁶	NR	NR	2	0
Pt.14	7	M	T-ALL	No	0	46.37	No	Patient	1 × 10⁶	MRD(−) CRi	—	2	0
Pt.15	15	M	T-ALL	No	1	4.42	Yes	Patient	1 × 10⁶	MRD(−) CRi	CR	1	0
Pt.16	13	M	T-ALL	No	0	4.28	No	Patient	1 × 10⁶	MRD(−) CRi	—	2	0
Pt.17	21	F	T-ALL	No	0	56.01	No	Patient	0.5 × 10⁶	MRD(−) CRi	—	1	0
Pt.18	32	M	T-ALL	No	0	21.49	No	Patient	0.5 × 10⁶	MRD(−) CR	—	2	0
Pt.19	36	F	T-LBL	Yes	6	10.76	Yes	Patient	1 × 10⁶	MRD(−) CRi	PD	1	0
Pt.20	22	M	T-ALL	No	0	56.63	No	Patient	1 × 10⁶	MRD(−) CRi	—	1	0

F, female; M, male; NR, no response; Pt., patient.

EMD remitted at enrollment due to prior mediastinal radiotherapy.