Characteristics associated with differences in neurocognitive domains among autologous HCT survivors, assessed by the Childhood Cancer Survivor Study NCQ
| Characteristic . | N . | Emotional regulation . | Task efficiency . | Organization . | Memory . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Z-score, mean (95% CI) . | % Impaired* . | Z-score, mean (95% CI) . | % Impaired* . | Z-score, mean (95% CI) . | % Impaired* . | Z-score, mean (95% CI) . | % Impaired* . | ||
| Total | 633 | 0.26 (0.17-0.35)† | 17.4† | 0.84 (0.73-0.95)† | 34.7† | 0.33 (0.23-0.42)† | 24.3† | 0.74 (0.64-0.85)† | 31.1† |
| Sex | |||||||||
| Female | 301 | 0.32 (0.19-0.45) | 17.9 | 0.98 (0.82-1.14) | 38.6 | 0.40 (0.26-0.54) | 25.9 | 0.95 (0.80-1.10) | 35.0 |
| Male | 332 | 0.21 (0.09-0.33) | 16.9 | 0.71 (0.56-0.86) | 31.0 | 0.26 (0.13-0.39) | 22.9 | 0.56 (0.42-0.70)† | 27.6 |
| Time since initial transplant, y | |||||||||
| <5 | 188 | 0.26 (0.10-0.41) | 17.0 | 0.75 (0.56-0.95) | 33.0 | 0.22 (0.06-0.38) | 23.9 | 0.63 (0.44-0.82) | 28.0 |
| 5-10 | 185 | 0.41 (0.23-0.60) | 21.1 | 1.03 (0.81-1.25) | 39.5 | 0.44 (0.25-0.63) | 28.7 | 0.90 (0.70-1.10) | 35.1 |
| 10-1 | 99 | 0.27 (0.07-0.46) | 16.2 | 0.77 (0.53-1.02) | 31.0 | 0.31 (0.08-0.53) | 20.2 | 0.80 (0.57-1.03) | 35.0 |
| 15-20 | 70 | 0.13 (−0.14-0.41) | 14.3 | 0.74 (0.41-1.07) | 32.9 | 0.28 (−0.02-0.58) | 24.3 | 0.65 (0.34-0.97) | 27.1 |
| 20-25 | 53 | −0.03 (−0.29-0.24) | 11.3 | 0.80 (0.44-1.17) | 31.5 | 0.36 (0.02-0.70) | 20.8 | 0.67 (0.32-1.02) | 25.9 |
| 25+ | 38 | 0.16 (−0.19-0.51) | 18.4 | 0.71 (0.26-1.15) | 36.8 | 0.36 (−0.05-0.78) | 21.1 | 0.71 (0.31-1.10) | 31.6 |
| Current age (by decade) | |||||||||
| <50 y | 51 | 0.43 (0.09-0.78) | 21.6 | 1.10 (0.66-1.53) | 47.1 | 0.41 (0.05-0.78) | 29.4 | 1.23 (0.79-1.67) | 45.1 |
| 50-59 y | 107 | 0.28 (0.04-0.52) | 16.8 | 0.70 (0.42-0.99) | 26.9 | 0.26 (0.00-0.51) | 24.3 | 0.72 (0.44-0.99) | 27.8 |
| 60-69 y | 253 | 0.30 (0.16-0.44) | 17.8 | 0.95 (0.78-1.13) | 38.2 | 0.45 (0.29-0.61) | 25.7 | 0.83 (0.66-099) | 34.5 |
| ≥70 y | 222 | 0.16 (0.02-0.30) | 16.2 | 0.71 (0.55-0.87) | 31.5 | 0.20 (0.06-0.34) | 21.6 | 0.55 (0.40-0.71) | 25.7 |
| Hearing issues | |||||||||
| No | 406 | 0.20 (0.09-0.31) | 16.0 | 0.67 (0.54-0.80) | 30.4 | 0.17 (0.06-0.28) | 19.7 | 0.62 (0.49-0.74) | 26.2 |
| Yes | 227 | 0.37 (0.22-0.52) | 19.8 | 1.14 (0.95-1.33)† | 42.3† | 0.61 (0.44-0.78)† | 32.6† | 0.98 (0.80-1.15)† | 40.1† |
| Stroke/seizures | |||||||||
| No | 565 | 0.24 (0.15-0.34) | 17.0 | 0.82 (0.70-0.93) | 34.7 | 0.29 (0.19-0.39) | 23.0 | 0.70 (0.59-0.81) | 29.8 |
| Yes | 55 | 0.35 (0.02-0.68) | 20.0 | 1.02 (0.66-1.37) | 34.6 | 0.59 (0.25-0.92) | 32.7 | 1.14 (0.76-1.52) | 41.8 |
| Sleep disturbance | |||||||||
| No (T-score <60) | 587 | 0.22 (0.12-0.31) | 16.9 | 0.75 (0.64-0.86) | 32.1 | 0.27 (0.18-0.37) | 23.0 | 0.68 (0.58-0.79) | 29.5 |
| Yes (T-score ≥60) | 46 | 0.85 (0.52-1.17)† | 23.9 | 1.95 (1.56-2.33)† | 67.4† | 1.01 (0.61-1.41)† | 41.3† | 1.54 (1.16-1.91)† | 52.2† |
| Characteristic . | N . | Emotional regulation . | Task efficiency . | Organization . | Memory . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Z-score, mean (95% CI) . | % Impaired* . | Z-score, mean (95% CI) . | % Impaired* . | Z-score, mean (95% CI) . | % Impaired* . | Z-score, mean (95% CI) . | % Impaired* . | ||
| Total | 633 | 0.26 (0.17-0.35)† | 17.4† | 0.84 (0.73-0.95)† | 34.7† | 0.33 (0.23-0.42)† | 24.3† | 0.74 (0.64-0.85)† | 31.1† |
| Sex | |||||||||
| Female | 301 | 0.32 (0.19-0.45) | 17.9 | 0.98 (0.82-1.14) | 38.6 | 0.40 (0.26-0.54) | 25.9 | 0.95 (0.80-1.10) | 35.0 |
| Male | 332 | 0.21 (0.09-0.33) | 16.9 | 0.71 (0.56-0.86) | 31.0 | 0.26 (0.13-0.39) | 22.9 | 0.56 (0.42-0.70)† | 27.6 |
| Time since initial transplant, y | |||||||||
| <5 | 188 | 0.26 (0.10-0.41) | 17.0 | 0.75 (0.56-0.95) | 33.0 | 0.22 (0.06-0.38) | 23.9 | 0.63 (0.44-0.82) | 28.0 |
| 5-10 | 185 | 0.41 (0.23-0.60) | 21.1 | 1.03 (0.81-1.25) | 39.5 | 0.44 (0.25-0.63) | 28.7 | 0.90 (0.70-1.10) | 35.1 |
| 10-1 | 99 | 0.27 (0.07-0.46) | 16.2 | 0.77 (0.53-1.02) | 31.0 | 0.31 (0.08-0.53) | 20.2 | 0.80 (0.57-1.03) | 35.0 |
| 15-20 | 70 | 0.13 (−0.14-0.41) | 14.3 | 0.74 (0.41-1.07) | 32.9 | 0.28 (−0.02-0.58) | 24.3 | 0.65 (0.34-0.97) | 27.1 |
| 20-25 | 53 | −0.03 (−0.29-0.24) | 11.3 | 0.80 (0.44-1.17) | 31.5 | 0.36 (0.02-0.70) | 20.8 | 0.67 (0.32-1.02) | 25.9 |
| 25+ | 38 | 0.16 (−0.19-0.51) | 18.4 | 0.71 (0.26-1.15) | 36.8 | 0.36 (−0.05-0.78) | 21.1 | 0.71 (0.31-1.10) | 31.6 |
| Current age (by decade) | |||||||||
| <50 y | 51 | 0.43 (0.09-0.78) | 21.6 | 1.10 (0.66-1.53) | 47.1 | 0.41 (0.05-0.78) | 29.4 | 1.23 (0.79-1.67) | 45.1 |
| 50-59 y | 107 | 0.28 (0.04-0.52) | 16.8 | 0.70 (0.42-0.99) | 26.9 | 0.26 (0.00-0.51) | 24.3 | 0.72 (0.44-0.99) | 27.8 |
| 60-69 y | 253 | 0.30 (0.16-0.44) | 17.8 | 0.95 (0.78-1.13) | 38.2 | 0.45 (0.29-0.61) | 25.7 | 0.83 (0.66-099) | 34.5 |
| ≥70 y | 222 | 0.16 (0.02-0.30) | 16.2 | 0.71 (0.55-0.87) | 31.5 | 0.20 (0.06-0.34) | 21.6 | 0.55 (0.40-0.71) | 25.7 |
| Hearing issues | |||||||||
| No | 406 | 0.20 (0.09-0.31) | 16.0 | 0.67 (0.54-0.80) | 30.4 | 0.17 (0.06-0.28) | 19.7 | 0.62 (0.49-0.74) | 26.2 |
| Yes | 227 | 0.37 (0.22-0.52) | 19.8 | 1.14 (0.95-1.33)† | 42.3† | 0.61 (0.44-0.78)† | 32.6† | 0.98 (0.80-1.15)† | 40.1† |
| Stroke/seizures | |||||||||
| No | 565 | 0.24 (0.15-0.34) | 17.0 | 0.82 (0.70-0.93) | 34.7 | 0.29 (0.19-0.39) | 23.0 | 0.70 (0.59-0.81) | 29.8 |
| Yes | 55 | 0.35 (0.02-0.68) | 20.0 | 1.02 (0.66-1.37) | 34.6 | 0.59 (0.25-0.92) | 32.7 | 1.14 (0.76-1.52) | 41.8 |
| Sleep disturbance | |||||||||
| No (T-score <60) | 587 | 0.22 (0.12-0.31) | 16.9 | 0.75 (0.64-0.86) | 32.1 | 0.27 (0.18-0.37) | 23.0 | 0.68 (0.58-0.79) | 29.5 |
| Yes (T-score ≥60) | 46 | 0.85 (0.52-1.17)† | 23.9 | 1.95 (1.56-2.33)† | 67.4† | 1.01 (0.61-1.41)† | 41.3† | 1.54 (1.16-1.91)† | 52.2† |