Table 3. Characteristics associated with... | American Society of Hematology

Table 3.

Characteristics associated with differences in neurocognitive domains among allogeneic HCT survivors, assessed by the Childhood Cancer Survivor Study NCQ

Characteristic	N	Emotional regulation		Task efficiency		Organization		Memory
Characteristic	N	Z-score, mean (95% CI)	% Impaired*	Z-score, mean (95% CI)	% Impaired*	Z-score, mean (95% CI)	% Impaired*	Z-score, mean (95% CI)	% Impaired*
Total	1210	0.22 (0.16-0.29)†	17.4†	0.69 (0.61-0.77)†	31.2†	0.21 (0.15-0.28)†	20.9†	0.61 (0.54-0.69)†	26.0†
Sex
Female	578	0.27 (0.17-0.36)	18.2	0.79 (0.67-0.90)	32.5	0.29 (0.19-0.39)	23.5	0.78 (0.68-0.88)	29.4
Male	633	0.18 (0.09-0.27)	16.6	0.60 (0.50-0.71)	30.0	0.14 (0.06-0.23)	18.5	0.46 (0.37-0.56)†	22.9†
Time since initial transplant, y
<5	184	0.28 (0.10-0.46)	19.6	0.80 (0.60-1.00)	31.9	0.28 (0.10-0.46)	21.5	0.63 (0.43-0.83)	26.1
5-10	253	0.29 (0.14-0.43)	19.0	0.79 (0.62-0.95)	37.2	0.25 (0.10-0.41)	21.4	0.64 (0.48-0.79)	25.4
10-15	168	0.12 (-0.05-0.28)	11.3	0.59 (0.39-0.79)	27.4	0.18 (0.00-0.36)	20.8	0.62 (0.42-0.82)	26.2
15-2	188	0.25 (0.09-0.41)	21.3	0.71 (0.54-0.89)	30.7	0.22 (0.07-0.37)	19.7	0.66 (0.49-0.83)	27.7
20-25	170	0.10 (-0.07-0.26)	12.4	0.55 (0.34-0.76)	25.9	0.13 (-0.03-0.30)	22.4	0.49 (0.30-0.68)	22.9
25+	247	0.26 (0.12-0.40)	18.6	0.66 (0.48-0.84)	31.1	0.19 (0.06-0.32)	19.8	0.63 (0.47-0.79)	27.4
Current age (by decade)
<50 y	169	0.44 (0.24-0.64)	23.7	0.78 (0.59-0.98)	37.1	0.24 (0.06-0.42)	21.9	0.89 (0.67-1.10)	35.5
50-59 y	297	0.33 (0.19-0.46)	19.2	0.75 (0.58-0.92)	32.2	0.32 (0.18-0.45)	23.8	0.66 (0.51-0.82)	25.8
60-69 y	474	0.16 (0.06-0.25)	16.9	0.61 (0.49-0.73)	28.3	0.13 (0.03-0.24)	18.8	0.55 (0.43-0.66)	27.0
≥70 y	270	0.10 (-0.02-0.21)	12.2	0.71 (0.56-0.86)	31.4	0.22 (0.10-0.35)	20.7	0.51 (0.39-0.64)	18.6
Hearing issues
No	870	0.14 (0.07-0.22)	15.2	0.59 (0.51-0.68)	28.2	0.14 (0.07-0.22)	20.2	0.52 (0.44-0.60)	23.9
Yes	333	0.44 (0.32-0.57)†	23.4†	0.94 (0.78-1.09)†	38.6†	0.37 (0.25-0.50)†	22.3	0.84 (0.70-0.98)†	31.1
Stroke/seizures
No	1069	0.20 (0.13-0.27)	16.7	0.63 (0.55-0.71)	29.3	0.19 (0.12-0.25)	20.2	0.56 (0.49-0.64)	24.6
Yes	122	0.41 (0.19-0.63)	23.0	1.19 (0.93-1.45)†	45.1†	0.37 (0.16-0.57)	24.6	0.97 (0.73-1.21)†	36.1†
Sleep disturbance
No (T-score <60)	1106	0.14 (0.08-0.21)	15.3	0.59 (0.51-0.66)	29.0	0.14 (0.08-0.21)	19.0	0.53 (0.45-0.60)	23.9
Yes (T-score ≥60)	102	1.07 (0.81-1.33)†	39.2†	1.73 (1.42-2.04)†	52.9†	0.94 (0.68-1.20)†	40.8†	1.53 (1.25-1.82)†	48.0†

Characteristic	N	Emotional regulation		Task efficiency		Organization		Memory
Characteristic	N	Z-score, mean (95% CI)	% Impaired*	Z-score, mean (95% CI)	% Impaired*	Z-score, mean (95% CI)	% Impaired*	Z-score, mean (95% CI)	% Impaired*
Total	1210	0.22 (0.16-0.29)†	17.4†	0.69 (0.61-0.77)†	31.2†	0.21 (0.15-0.28)†	20.9†	0.61 (0.54-0.69)†	26.0†
Sex
Female	578	0.27 (0.17-0.36)	18.2	0.79 (0.67-0.90)	32.5	0.29 (0.19-0.39)	23.5	0.78 (0.68-0.88)	29.4
Male	633	0.18 (0.09-0.27)	16.6	0.60 (0.50-0.71)	30.0	0.14 (0.06-0.23)	18.5	0.46 (0.37-0.56)†	22.9†
Time since initial transplant, y
<5	184	0.28 (0.10-0.46)	19.6	0.80 (0.60-1.00)	31.9	0.28 (0.10-0.46)	21.5	0.63 (0.43-0.83)	26.1
5-10	253	0.29 (0.14-0.43)	19.0	0.79 (0.62-0.95)	37.2	0.25 (0.10-0.41)	21.4	0.64 (0.48-0.79)	25.4
10-15	168	0.12 (-0.05-0.28)	11.3	0.59 (0.39-0.79)	27.4	0.18 (0.00-0.36)	20.8	0.62 (0.42-0.82)	26.2
15-2	188	0.25 (0.09-0.41)	21.3	0.71 (0.54-0.89)	30.7	0.22 (0.07-0.37)	19.7	0.66 (0.49-0.83)	27.7
20-25	170	0.10 (-0.07-0.26)	12.4	0.55 (0.34-0.76)	25.9	0.13 (-0.03-0.30)	22.4	0.49 (0.30-0.68)	22.9
25+	247	0.26 (0.12-0.40)	18.6	0.66 (0.48-0.84)	31.1	0.19 (0.06-0.32)	19.8	0.63 (0.47-0.79)	27.4
Current age (by decade)
<50 y	169	0.44 (0.24-0.64)	23.7	0.78 (0.59-0.98)	37.1	0.24 (0.06-0.42)	21.9	0.89 (0.67-1.10)	35.5
50-59 y	297	0.33 (0.19-0.46)	19.2	0.75 (0.58-0.92)	32.2	0.32 (0.18-0.45)	23.8	0.66 (0.51-0.82)	25.8
60-69 y	474	0.16 (0.06-0.25)	16.9	0.61 (0.49-0.73)	28.3	0.13 (0.03-0.24)	18.8	0.55 (0.43-0.66)	27.0
≥70 y	270	0.10 (-0.02-0.21)	12.2	0.71 (0.56-0.86)	31.4	0.22 (0.10-0.35)	20.7	0.51 (0.39-0.64)	18.6
Hearing issues
No	870	0.14 (0.07-0.22)	15.2	0.59 (0.51-0.68)	28.2	0.14 (0.07-0.22)	20.2	0.52 (0.44-0.60)	23.9
Yes	333	0.44 (0.32-0.57)†	23.4†	0.94 (0.78-1.09)†	38.6†	0.37 (0.25-0.50)†	22.3	0.84 (0.70-0.98)†	31.1
Stroke/seizures
No	1069	0.20 (0.13-0.27)	16.7	0.63 (0.55-0.71)	29.3	0.19 (0.12-0.25)	20.2	0.56 (0.49-0.64)	24.6
Yes	122	0.41 (0.19-0.63)	23.0	1.19 (0.93-1.45)†	45.1†	0.37 (0.16-0.57)	24.6	0.97 (0.73-1.21)†	36.1†
Sleep disturbance
No (T-score <60)	1106	0.14 (0.08-0.21)	15.3	0.59 (0.51-0.66)	29.0	0.14 (0.08-0.21)	19.0	0.53 (0.45-0.60)	23.9
Yes (T-score ≥60)	102	1.07 (0.81-1.33)†	39.2†	1.73 (1.42-2.04)†	52.9†	0.94 (0.68-1.20)†	40.8†	1.53 (1.25-1.82)†	48.0†

Impaired defined as Z-score > 1.28, with higher scores indicating greater impairment.

†

Significantly different (P < .01) vs value of 0 (for mean total Z-score), 10% (for % impaired), or value above (for all 2-level categorical variables).

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