Characteristics of patients
| . | . | AIC at splenectomy . | ||
|---|---|---|---|---|
| . | Total . | cITP . | AIHA . | ES . |
| Patients, no. (%) | 161 | 120 (74) | 19 (12) | 22 (14) |
| Sex ratio (male/female) | 1.1 (83/78) | 1.0 (59/61) | 0.9 (9/10) | 2.1 (15/7) |
| IM in first-degree relative, n (%) | 25 (16) | 13 (11) | 4 (21) | 8 (36) |
| Cancer in first-degree relative, n (%) | 5 (3) | 2 (2) | 2 (11) | 1 (5) |
| Age, y | ||||
| First AIC, median (min-max) | 7.3 (0.6-17.4) | 8.4 (0.7-14.1) | 3.9 (0.6-17.4) | 5.3 (1.7-15.8) |
| Second AIC, median (min-max) | 7.0 (1.8-16.6) | NA | NA | 7.0 (1.8-16.6) |
| IM at any time point during follow-up, n (%) | 52 (32) | 25 (21) | 8 (42) | 19 (86) |
| First IM before splenectomy, n (%) | 34 (21) | 14 (12) | 3 (16) | 17 (85) |
| First IM after splenectomy, n (%) | 18 (11) | 11 (9) | 5 (26) | 2 (1) |
| Splenectomy as first second-line treatment, n (%)* | 80 (50) | 66 (55) | 8 (42) | 6 (27) |
| Number of second-line treatments before splenectomy, median (min-max) | 1 (0-8) | 0 (0-8) | 1 (0-3) | 1 (0-5) |
| Time from first AIC to splenectomy, median (min-max), y | 2.3 (0.1-13.5) | 2.3 (0.1-13.5) | 1.3 (0.1-10.0) | 4.5 (0.1-12.1) |
| Age at splenectomy, median (min-max), y† | 11.2 (0.8-17.7) | 11.8 (2.0-17.7) | 4.9 (0.8-17.6) | 10.6 (4.1-17.7) |
| Second AIC (ie, diagnosis of ES) after splenectomy, n (%) | 8/139 (6) | 5 (4) | 3 (16) | NA |
| Duration of follow-up, y | ||||
| After splenectomy, median (min-max)‡ | 6.8 (1.0-33.3) | 6.0 (1.0-28.1) | 9.9 (3.6-16.7) | 12.4 (1.1-33.3) |
| After first AIC, median (min-max) | 11.0 (1.7-38.6) | 9.3 (1.7-29.3) | 12.7 (4.2-16.8) | 18.1 (5.1-38.6) |
| . | . | AIC at splenectomy . | ||
|---|---|---|---|---|
| . | Total . | cITP . | AIHA . | ES . |
| Patients, no. (%) | 161 | 120 (74) | 19 (12) | 22 (14) |
| Sex ratio (male/female) | 1.1 (83/78) | 1.0 (59/61) | 0.9 (9/10) | 2.1 (15/7) |
| IM in first-degree relative, n (%) | 25 (16) | 13 (11) | 4 (21) | 8 (36) |
| Cancer in first-degree relative, n (%) | 5 (3) | 2 (2) | 2 (11) | 1 (5) |
| Age, y | ||||
| First AIC, median (min-max) | 7.3 (0.6-17.4) | 8.4 (0.7-14.1) | 3.9 (0.6-17.4) | 5.3 (1.7-15.8) |
| Second AIC, median (min-max) | 7.0 (1.8-16.6) | NA | NA | 7.0 (1.8-16.6) |
| IM at any time point during follow-up, n (%) | 52 (32) | 25 (21) | 8 (42) | 19 (86) |
| First IM before splenectomy, n (%) | 34 (21) | 14 (12) | 3 (16) | 17 (85) |
| First IM after splenectomy, n (%) | 18 (11) | 11 (9) | 5 (26) | 2 (1) |
| Splenectomy as first second-line treatment, n (%)* | 80 (50) | 66 (55) | 8 (42) | 6 (27) |
| Number of second-line treatments before splenectomy, median (min-max) | 1 (0-8) | 0 (0-8) | 1 (0-3) | 1 (0-5) |
| Time from first AIC to splenectomy, median (min-max), y | 2.3 (0.1-13.5) | 2.3 (0.1-13.5) | 1.3 (0.1-10.0) | 4.5 (0.1-12.1) |
| Age at splenectomy, median (min-max), y† | 11.2 (0.8-17.7) | 11.8 (2.0-17.7) | 4.9 (0.8-17.6) | 10.6 (4.1-17.7) |
| Second AIC (ie, diagnosis of ES) after splenectomy, n (%) | 8/139 (6) | 5 (4) | 3 (16) | NA |
| Duration of follow-up, y | ||||
| After splenectomy, median (min-max)‡ | 6.8 (1.0-33.3) | 6.0 (1.0-28.1) | 9.9 (3.6-16.7) | 12.4 (1.1-33.3) |
| After first AIC, median (min-max) | 11.0 (1.7-38.6) | 9.3 (1.7-29.3) | 12.7 (4.2-16.8) | 18.1 (5.1-38.6) |
NA, not applicable; SD, standard deviation.
Rate has evolved with splenectomy year: before 2000, 12/22 (55%), 2000-2009, 61/108 (56%), from 2010, 7/31 (23%).
Patients who underwent splenectomy for an AIHA were younger than the rest of the cohort, P = .0005.
Patients with cITP had a shorter postsplenectomy follow-up than the rest of the cohort, P = 4.7 × 10-6.