Location and cause of bleeds for the total population and per hemophilia severity during the follow-up duration
| . | Total cohort (N = 304) . | Severity . | ||||
|---|---|---|---|---|---|---|
| Moderate hemophilia (n = 70) . | Mild hemophilia (n = 234) . | Mild 0.05-0.15 IU/mL (n = 114) . | Mild 0.15-0.25 IU/mL (n = 80) . | Mild >0.25 IU/mL (n = 40) . | ||
| Total no. of bleeds (subjects with bleeds) | 1523 (236) | 762 (63) | 761 (173) | 477 (88) | 214 (62) | 70 (23) |
| Location of bleed | ||||||
| Joint | 482 (32) | 274 (36) | 208 (27) | 139 (29) | 53 (25) | 16 (23) |
| Muscle | 423 (28) | 230 (30) | 193 (25) | 132 (28) | 51 (24) | 10 (14) |
| Subcutaneous | 345 (23) | 155 (20) | 190 (25) | 114 (24) | 53 (25) | 23 (33) |
| Mucosal | 114 (7) | 30 (4) | 84 (11) | 42 (9) | 31 (14) | 11 (16) |
| Intracranial hemorrhage | 3 (0.2) | 0 (0) | 3 (0.4) | 1 (0.2) | 2 (0.5) | 0 (0) |
| Other | 138 (9) | 64 (8) | 74 (10) | 42 (9) | 23 (11) | 9 (13) |
| Unknown | 18 (1) | 9 (1) | 9 (1) | 7 (1) | 1 (0) | 1 (1) |
| Cause of bleed | ||||||
| Spontaneous | 171 (11) | 117 (15) | 54 (7) | 38 (8) | 13 (6) | 3 (4) |
| Nonspontaneous | 1020 (67) | 404 (53) | 616 (81) | 351 (79) | 177 (83) | 58 (83) |
| Trauma related | 768 (50) | 288 (38) | 480 (63) | 300 (63) | 136 (64) | 44 (63) |
| Activity related | 138 (9) | 78 (10) | 60 (8) | 42 (9) | 15 (7) | 3 (4) |
| Unknown | 332 (22) | 241 (32) | 91 (12) | 58 (12) | 24 (11) | 9 (13) |
| . | Total cohort (N = 304) . | Severity . | ||||
|---|---|---|---|---|---|---|
| Moderate hemophilia (n = 70) . | Mild hemophilia (n = 234) . | Mild 0.05-0.15 IU/mL (n = 114) . | Mild 0.15-0.25 IU/mL (n = 80) . | Mild >0.25 IU/mL (n = 40) . | ||
| Total no. of bleeds (subjects with bleeds) | 1523 (236) | 762 (63) | 761 (173) | 477 (88) | 214 (62) | 70 (23) |
| Location of bleed | ||||||
| Joint | 482 (32) | 274 (36) | 208 (27) | 139 (29) | 53 (25) | 16 (23) |
| Muscle | 423 (28) | 230 (30) | 193 (25) | 132 (28) | 51 (24) | 10 (14) |
| Subcutaneous | 345 (23) | 155 (20) | 190 (25) | 114 (24) | 53 (25) | 23 (33) |
| Mucosal | 114 (7) | 30 (4) | 84 (11) | 42 (9) | 31 (14) | 11 (16) |
| Intracranial hemorrhage | 3 (0.2) | 0 (0) | 3 (0.4) | 1 (0.2) | 2 (0.5) | 0 (0) |
| Other | 138 (9) | 64 (8) | 74 (10) | 42 (9) | 23 (11) | 9 (13) |
| Unknown | 18 (1) | 9 (1) | 9 (1) | 7 (1) | 1 (0) | 1 (1) |
| Cause of bleed | ||||||
| Spontaneous | 171 (11) | 117 (15) | 54 (7) | 38 (8) | 13 (6) | 3 (4) |
| Nonspontaneous | 1020 (67) | 404 (53) | 616 (81) | 351 (79) | 177 (83) | 58 (83) |
| Trauma related | 768 (50) | 288 (38) | 480 (63) | 300 (63) | 136 (64) | 44 (63) |
| Activity related | 138 (9) | 78 (10) | 60 (8) | 42 (9) | 15 (7) | 3 (4) |
| Unknown | 332 (22) | 241 (32) | 91 (12) | 58 (12) | 24 (11) | 9 (13) |
Data are presented as no. (%); percentages are rounded to whole numbers. Mucosal indicates epistaxis and oral cavity bleeds. Non-spontaneous indicates trauma-related, activity-related, surgery-related, tooth extraction, underlying disease, or other provoking factors.