Bleeding rates and numbers of patients with zero bleeds during the study follow-up period
| . | Total cohort (N = 304) . | Severity . | ||||
|---|---|---|---|---|---|---|
| Moderate hemophilia (n = 70) . | Mild hemophilia (n = 234) . | Mild 0.05-0.15 IU/mL (n = 114) . | Mild 0.15-0.25 IU/mL (n = 80) . | Mild >0.25 IU/mL (n = 40) . | ||
| Bleeding rates | ||||||
| ABR, median (IQR) | 0.2 (0.1-0.5) | 0.6 (0.2-1.4) | 0.2 (0.0-0.4) | 0.3 (0.1-0.5) | 0.2 (0.1-0.4) | 0.1 (0-0.2) |
| Range: minimum-maximum | 0-10.9 | 0-10.9 | 0-3.1 | 0-3.1 | 0-1.8 | 0-1.9 |
| sABR, median (IQR) | 0 (0-0) | 0.1 (0-0.2) | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) |
| Range: minimum-maximum | 0-2.4 | 0-2.4 | 0-0.5 | 0-0.5 | 0-0.5 | 0-0.2 |
| AJBR, median (IQR) | 0 (0-0.2) | 0.2 (0-0.4) | 0 (0-0.1) | 0 (0-0.2) | 0 (0-0.1) | 0 (0-0) |
| Range: minimum-maximum | 0-4.0 | 0-4.0 | 0-1.3 | 0-1.3 | 0-0.9 | 0-0.6 |
| sAJBR, median (IQR) | 0 (0-0) | 0 (0-0.1) | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) |
| Range: minimum-maximum | 0-1.2 | 0-1.2 | 0-0.5 | 0-0.3 | 0-0.5 | 0-0 |
| Patients with zero bleeds, no. (%) | ||||||
| Zero bleeds | 68 (22) | 7 (10) | 61 (26) | 26 (23) | 18 (23) | 17 (43) |
| Zero spontaneous bleeds | 230 (76) | 31 (44) | 199 (85) | 89 (78) | 72 (90) | 38 (95) |
| Zero joint bleeds | 183 (60) | 21 (30) | 162 (69) | 71 (62) | 58 (73) | 33 (83) |
| Zero spontaneous joint bleeds | 267 (88) | 48 (69) | 219 (94) | 102 (90) | 77 (96) | 40 (100) |
| . | Total cohort (N = 304) . | Severity . | ||||
|---|---|---|---|---|---|---|
| Moderate hemophilia (n = 70) . | Mild hemophilia (n = 234) . | Mild 0.05-0.15 IU/mL (n = 114) . | Mild 0.15-0.25 IU/mL (n = 80) . | Mild >0.25 IU/mL (n = 40) . | ||
| Bleeding rates | ||||||
| ABR, median (IQR) | 0.2 (0.1-0.5) | 0.6 (0.2-1.4) | 0.2 (0.0-0.4) | 0.3 (0.1-0.5) | 0.2 (0.1-0.4) | 0.1 (0-0.2) |
| Range: minimum-maximum | 0-10.9 | 0-10.9 | 0-3.1 | 0-3.1 | 0-1.8 | 0-1.9 |
| sABR, median (IQR) | 0 (0-0) | 0.1 (0-0.2) | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) |
| Range: minimum-maximum | 0-2.4 | 0-2.4 | 0-0.5 | 0-0.5 | 0-0.5 | 0-0.2 |
| AJBR, median (IQR) | 0 (0-0.2) | 0.2 (0-0.4) | 0 (0-0.1) | 0 (0-0.2) | 0 (0-0.1) | 0 (0-0) |
| Range: minimum-maximum | 0-4.0 | 0-4.0 | 0-1.3 | 0-1.3 | 0-0.9 | 0-0.6 |
| sAJBR, median (IQR) | 0 (0-0) | 0 (0-0.1) | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) |
| Range: minimum-maximum | 0-1.2 | 0-1.2 | 0-0.5 | 0-0.3 | 0-0.5 | 0-0 |
| Patients with zero bleeds, no. (%) | ||||||
| Zero bleeds | 68 (22) | 7 (10) | 61 (26) | 26 (23) | 18 (23) | 17 (43) |
| Zero spontaneous bleeds | 230 (76) | 31 (44) | 199 (85) | 89 (78) | 72 (90) | 38 (95) |
| Zero joint bleeds | 183 (60) | 21 (30) | 162 (69) | 71 (62) | 58 (73) | 33 (83) |
| Zero spontaneous joint bleeds | 267 (88) | 48 (69) | 219 (94) | 102 (90) | 77 (96) | 40 (100) |
Percentages have been rounded to whole numbers. sABR, spontaneous annual bleeding rate; sAJBR, spontaneous annual joint bleeding rate.