Gene sets from GSEA that reached an FDR-corrected threshold (q < 0.05) in both cohorts
| Gene set name . | Discovery FDR value . | Significant genes/all genes . | Replication FDR value . | Significant genes/ all genes . |
|---|---|---|---|---|
| KEGG: LEUKOCYTE TRANSENDOTHELIAL MIGRATION | 0.006 | 83/117 | 0.0477 | 79/117 |
| GO: INNATE IMMUNE RESPONSE | 0.023 | 18/23 | 0.019 | 19/23 |
| GO: LYASE ACTIVITY | 0.031 | 48/69 | 0.0471 | 52/69 |
| Gene set name . | Discovery FDR value . | Significant genes/all genes . | Replication FDR value . | Significant genes/ all genes . |
|---|---|---|---|---|
| KEGG: LEUKOCYTE TRANSENDOTHELIAL MIGRATION | 0.006 | 83/117 | 0.0477 | 79/117 |
| GO: INNATE IMMUNE RESPONSE | 0.023 | 18/23 | 0.019 | 19/23 |
| GO: LYASE ACTIVITY | 0.031 | 48/69 | 0.0471 | 52/69 |
The “KEGG: Leukocyte Transendothelial Migration” pathway involves the process of leukocytes binding to endothelial adhesion molecules and migrating across the endothelial tissue. The “GO: Innate Immune Response” (GO:0045087) pathway encompasses the defense response mediated by germline-encoded components that directly recognize components of potential pathogens. “GO: Lyase Activity” (the third replicated gene set) involves the class of enzymes which catalyze the cleavage of bonds including carbon–carbon, carbon–oxygen, or carbon–nitrogen, including enzymes that convert ATP (or GTP) to cAMP (cGMP).