Variable stratification by VWD type
| VWD type . | N . | Geometric mean VWF:Ag . | Median ISTH BAT score . | % with CADD >20 . | Average rare nonsynonymous variants per person . | P vs healthy . |
|---|---|---|---|---|---|---|
| Healthy controls | 210 | 104.8 | 1 | 0 | 0.16 | — |
| Low VWF | 169 | 45.7 | 4 | 13 | 0.67 | 2.4 × 10−13 |
| Type 1 | 153 | 17.9 | 5 | 18 | 1.26 | 1.6 × 10−27 |
| Type 2 | 165 | 45.1 | 9 | 40 | 1.47 | 3.5 × 10−60 |
| Type 3 | 39 | 6.2 | 15 | 55 | 1.5 | 2.7 × 10−34 |
| VWD type . | N . | Geometric mean VWF:Ag . | Median ISTH BAT score . | % with CADD >20 . | Average rare nonsynonymous variants per person . | P vs healthy . |
|---|---|---|---|---|---|---|
| Healthy controls | 210 | 104.8 | 1 | 0 | 0.16 | — |
| Low VWF | 169 | 45.7 | 4 | 13 | 0.67 | 2.4 × 10−13 |
| Type 1 | 153 | 17.9 | 5 | 18 | 1.26 | 1.6 × 10−27 |
| Type 2 | 165 | 45.1 | 9 | 40 | 1.47 | 3.5 × 10−60 |
| Type 3 | 39 | 6.2 | 15 | 55 | 1.5 | 2.7 × 10−34 |
Geometric mean of VWF:Ag and median ISTH BAT score, the percentage with CADD >20, and average number of rare nonsynonymous variants per person, stratified by VWD type. P values are comparing the average number of rare nonsynonymous variants in each type of VWD to healthy individuals.
—, no comparison.