Prophylactic consumption of rVWF through month 12
| . | Prior on-demand group (n = 13) . | Switch group (n = 10) . |
|---|---|---|
| Total no. of prophylactic infusions administered | 846 | 878 |
| Initial dosing frequency, n (%) | ||
| Once weekly | 0 (0) | 1 (10.0) |
| Twice weekly | 13 (100) | 8 (80.0) |
| 3 times weekly | 0 (0) | 1 (10.0) |
| Patients with ≥1 increase in dosing regimen, n (%) | 1 (7.7) | 2 (20.0) |
| Infusions per patient | ||
| Mean (SD) | 65.1 (38.4) | 87.8 (30.2) |
| Median (range) | 67.0 (2-116) | 104.5 (31-116) |
| No. of weekly infusions per patient | ||
| Mean (SD) | 1.9 (0.7) | 1.9 (0.4) |
| Median (range) | 1.9 (0.7-3.5) | 2.0 (0.8-2.1) |
| Average weight-adjusted rVWF dose per infusion, IU/kg | ||
| Mean (SD) | 52.2 (3.8) | 52.2 (16.2) |
| Median (range) | 52.9 (44.8-58.8) | 55.9 (24.4-79.4) |
| Weight-adjusted weekly rVWF dose per patient, IU/kg | ||
| Mean (SD) | 98.6 (40.6) | 94.0 (30.4) |
| Median (range) | 95.6 (34.9-187.8) | 106.8 (48.0-128.0) |
| . | Prior on-demand group (n = 13) . | Switch group (n = 10) . |
|---|---|---|
| Total no. of prophylactic infusions administered | 846 | 878 |
| Initial dosing frequency, n (%) | ||
| Once weekly | 0 (0) | 1 (10.0) |
| Twice weekly | 13 (100) | 8 (80.0) |
| 3 times weekly | 0 (0) | 1 (10.0) |
| Patients with ≥1 increase in dosing regimen, n (%) | 1 (7.7) | 2 (20.0) |
| Infusions per patient | ||
| Mean (SD) | 65.1 (38.4) | 87.8 (30.2) |
| Median (range) | 67.0 (2-116) | 104.5 (31-116) |
| No. of weekly infusions per patient | ||
| Mean (SD) | 1.9 (0.7) | 1.9 (0.4) |
| Median (range) | 1.9 (0.7-3.5) | 2.0 (0.8-2.1) |
| Average weight-adjusted rVWF dose per infusion, IU/kg | ||
| Mean (SD) | 52.2 (3.8) | 52.2 (16.2) |
| Median (range) | 52.9 (44.8-58.8) | 55.9 (24.4-79.4) |
| Weight-adjusted weekly rVWF dose per patient, IU/kg | ||
| Mean (SD) | 98.6 (40.6) | 94.0 (30.4) |
| Median (range) | 95.6 (34.9-187.8) | 106.8 (48.0-128.0) |