Table 2. Cox proportional hazards... | American Society of Hematology

Table 2.

Cox proportional hazards multivariable analysis of factor association with OS among FL patients with 1 or more TP53 mutations

Parameter*	Full model (N = 237 with 219 events)			Reduced model
	HR (95% CI)	Individual P	Overall P	HR (95% CI)	Individual P	Overall P
Age, y, continuous	1.01 (0.99, 1.02)	.3655	.3655
Cytogenetic risk group
Intermediate/favorable (N = 213; 89.9%) vs adverse (N = 24; 10.1%)	0.43 (0.24, 0.77)	.0046	.0046	0.45 (0.27, 0.74)	.0018	.0018
Allo-SCT†
Yes (N = 23; 9.7%) vs no (N = 214; 90.3%)	0.54 (0.31, 0.95)	.0313	.0313	0.49 (0.30, 0.81)	.0052	.0052
TP53 CN
Loss (N = 113; 64.2%) vs intact (N = 63; 35.8%)	0.98 (0.67, 1.44)	.9191	.5932
TP53 mutation
>1 (N = 59; 24.9%) vs = 1 (N = 178; 75.1%)	1.81 (1.30, 2.52)	.0004	.0004	1.78 (1.30, 2.45)	.0004	.0004
TP53 VAF
>40% (N = 130; 54.8%) vs ≤40% (N = 107; 45.2%)	1.75 (1.32, 2.32)	.0001	.0001	1.71 (1.29, 2.26)	.0002	.0002

Parameter*	Full model (N = 237 with 219 events)			Reduced model
	HR (95% CI)	Individual P	Overall P	HR (95% CI)	Individual P	Overall P
Age, y, continuous	1.01 (0.99, 1.02)	.3655	.3655
Cytogenetic risk group
Intermediate/favorable (N = 213; 89.9%) vs adverse (N = 24; 10.1%)	0.43 (0.24, 0.77)	.0046	.0046	0.45 (0.27, 0.74)	.0018	.0018
Allo-SCT†
Yes (N = 23; 9.7%) vs no (N = 214; 90.3%)	0.54 (0.31, 0.95)	.0313	.0313	0.49 (0.30, 0.81)	.0052	.0052
TP53 CN
Loss (N = 113; 64.2%) vs intact (N = 63; 35.8%)	0.98 (0.67, 1.44)	.9191	.5932
TP53 mutation
>1 (N = 59; 24.9%) vs = 1 (N = 178; 75.1%)	1.81 (1.30, 2.52)	.0004	.0004	1.78 (1.30, 2.45)	.0004	.0004
TP53 VAF
>40% (N = 130; 54.8%) vs ≤40% (N = 107; 45.2%)	1.75 (1.32, 2.32)	.0001	.0001	1.71 (1.29, 2.26)	.0002	.0002

N = 237 except for allo-SCT, N = 176.

Analyzed as a time-dependent covariate.

Boldface highlights significant P values.