Different types of immune effectors included in the study
. | Neo marker gene . | TGF-β DNR . | CAR/cytokine . | CAR . | iC9 . |
---|---|---|---|---|---|
Auto-VSTs | + | + | |||
Donor VSTs | + | + | + | ||
Donor allodepleted ATCs | + | ||||
Auto ATCs | + | + | + | ||
PA317* | + | ||||
PG13† | + | + | + | + |
. | Neo marker gene . | TGF-β DNR . | CAR/cytokine . | CAR . | iC9 . |
---|---|---|---|---|---|
Auto-VSTs | + | + | |||
Donor VSTs | + | + | + | ||
Donor allodepleted ATCs | + | ||||
Auto ATCs | + | + | + | ||
PA317* | + | ||||
PG13† | + | + | + | + |
allo, allogeneic; ATC, activated T cell; auto, autologous; DNR, dominant-negative receptor; iC9, inducible caspase 9.
PA317: amphitropic retrovirus packaging cell line was used for auto-VSTs and donor VSTs (obtained by Genetic Therapy Inc).
PG13: murine embryonic fibroblastic PG13 packaging cell lines (obtained from ATCC; #CRL-10686) were used for all other GRV-IEC types.