Association between out-of-hospital systemic corticosteroids and hospitalization for VOE: result of principal, subgroup, and sensitivity analyses
| . | . | . | Multivariate analysis by exposure to HU . | |
|---|---|---|---|---|
| . | Univariate analysis . | Multivariate analysis . | Adjusted OR* (95% CI) . | |
| Crude OR (95% CI) . | Adjusted OR* (95% CI) . | With HU . | Without HU . | |
| Principal analysis | ||||
| All patients (N = 5151) | 4.8 (3.1-7.4) | 3.8 (2.4-5.6) | 2.6 (1.1-6.4) | 4.0 (2.5-6.3) |
| Subgroup analysis | ||||
| Age ≥15 y (n = 2743) | 5.6 (3.0-10.5) | 4.5 (2.4-8.4) | NA | NA |
| Age <15 y (n = 2408) | 3.5 (1.5-6.6) | 2.8 (1.5-5.3) | NA | NA |
| Men (n = 2373) | 2.7 (1.5-5.1) | 2.1 (1.1-4.0) | NA | NA |
| Women (n = 2778) | 7.9 (4.3-14.6) | 6.5 (3.5-12.3) | NA | NA |
| Sensitivity analyses | ||||
| CTC† (n = 4725) | 4.9 (3.4-7.1) | 3.7 (2.5-5.4) | 3.4 (1.3-8.7) | 3.7 (2.5-5.6) |
| CCO‡ (n = 10 648) | 3.8 (3.1-4.5) | 3.0 (2.5-3.6) | 3.1 (1.7-5.8) | 3.0 (2.4-3.7) |
| CCO§ (n = 8852) | 5.2 (4.1-6.5) | 4.4 (3.5-5.5) | NA | NA |
| CCTC‖ (n = 5746) | 6.5 (4.0-10.8) | 4.7 (2.8-7.9) | NA | NA |
| . | . | . | Multivariate analysis by exposure to HU . | |
|---|---|---|---|---|
| . | Univariate analysis . | Multivariate analysis . | Adjusted OR* (95% CI) . | |
| Crude OR (95% CI) . | Adjusted OR* (95% CI) . | With HU . | Without HU . | |
| Principal analysis | ||||
| All patients (N = 5151) | 4.8 (3.1-7.4) | 3.8 (2.4-5.6) | 2.6 (1.1-6.4) | 4.0 (2.5-6.3) |
| Subgroup analysis | ||||
| Age ≥15 y (n = 2743) | 5.6 (3.0-10.5) | 4.5 (2.4-8.4) | NA | NA |
| Age <15 y (n = 2408) | 3.5 (1.5-6.6) | 2.8 (1.5-5.3) | NA | NA |
| Men (n = 2373) | 2.7 (1.5-5.1) | 2.1 (1.1-4.0) | NA | NA |
| Women (n = 2778) | 7.9 (4.3-14.6) | 6.5 (3.5-12.3) | NA | NA |
| Sensitivity analyses | ||||
| CTC† (n = 4725) | 4.9 (3.4-7.1) | 3.7 (2.5-5.4) | 3.4 (1.3-8.7) | 3.7 (2.5-5.6) |
| CCO‡ (n = 10 648) | 3.8 (3.1-4.5) | 3.0 (2.5-3.6) | 3.1 (1.7-5.8) | 3.0 (2.4-3.7) |
| CCO§ (n = 8852) | 5.2 (4.1-6.5) | 4.4 (3.5-5.5) | NA | NA |
| CCTC‖ (n = 5746) | 6.5 (4.0-10.8) | 4.7 (2.8-7.9) | NA | NA |
CTC, case-time-control; HU, hydroxyurea; NA, not applicable.
Adjusted by out-of-hospital antibiotics and red-blood-cell transfusions.
CTC with matched general population controls.
CCO with the control period 84 days before the index date.
CCO with the control period 1 year before the index date.
CCTC with case and control periods of 14 days.