Table 2. Summary of B- and cTfh cell... | American Society of Hematology

Table 2.

Summary of B- and cTfh cell subsets at acute iTTP presentation and ADAMTS13 relapse compared with HCs

	Acute iTTP presentation (n = 22)	ADAMTS13 relapse (n = 24)
B-cell subsets (% CD19⁺ B cells)
Transitional cells (IgD⁺CD38⁺⁺)	↓	→
Naïve cells (IgD⁺CD38⁺)	→	↑
IgD⁺ memory cells (IgD⁺CD38^–)	→	↓
Post-GC memory cells (IgD^–CD38⁺)	↓	↓
Double-negative memory cells (IgD^–CD38^–)	→	↓
Plasmablasts (IgD^–CD38⁺⁺)	↑	→
CD80 expression on B-cell subsets
IgD⁺ memory cells (IgD⁺CD38^–)	↓	→
Post-GC memory cells (IgD^–CD38⁺)	→	↑
Double-negative memory cells (IgD^–CD38^–)	↓	↑
Circulating Tfh cells (% CD3⁺CD4⁺ cells)
CD4⁺ CXCR5⁺ (total cTfh cells)	↓	→
CD4⁺ CXCR5⁺ PD1⁺	↓	→
CD4+ CXCR5+ ICOS+	→	↑

	Acute iTTP presentation (n = 22)	ADAMTS13 relapse (n = 24)
B-cell subsets (% CD19⁺ B cells)
Transitional cells (IgD⁺CD38⁺⁺)	↓	→
Naïve cells (IgD⁺CD38⁺)	→	↑
IgD⁺ memory cells (IgD⁺CD38^–)	→	↓
Post-GC memory cells (IgD^–CD38⁺)	↓	↓
Double-negative memory cells (IgD^–CD38^–)	→	↓
Plasmablasts (IgD^–CD38⁺⁺)	↑	→
CD80 expression on B-cell subsets
IgD⁺ memory cells (IgD⁺CD38^–)	↓	→
Post-GC memory cells (IgD^–CD38⁺)	→	↑
Double-negative memory cells (IgD^–CD38^–)	↓	↑
Circulating Tfh cells (% CD3⁺CD4⁺ cells)
CD4⁺ CXCR5⁺ (total cTfh cells)	↓	→
CD4⁺ CXCR5⁺ PD1⁺	↓	→
CD4+ CXCR5+ ICOS+	→	↑

↓ decreased compared with HC; → no difference compared with HC; ↑ increased compared with HC.