Logistic regression models assessing the association between childhood ALL case/control status and HLA-KIR interaction
| Predicted genetic ancestry . | Type of score . | Unadjusted model . | Model adjusting for top 5 PCs . | ||
|---|---|---|---|---|---|
| Odds ratio (95% CI) . | P* . | Odds ratio (95% CI) . | P* . | ||
| Latino all races | Activation score | 0.60 (0.49-0.72) | <.001 | 0.59 (0.49-0.71) | <.001 |
| Inhibition score | 0.82 (0.66-1.01) | .066 | 0.81 (0.64-1.01) | .057 | |
| Non-Latino White | Activation score | 1.02 (0.78-1.32) | .907 | 1.03 (0.78-1.35) | .842 |
| Inhibition score | 0.94 (0.69-1.29) | .705 | 0.91 (0.66-1.27) | .592 | |
| Non-Latino Asian | Activation score | 0.65 (0.42-1.00) | .051 | 0.63 (0.38-1.01) | .052 |
| Inhibition score | 0.98 (0.59-1.62) | .945 | 0.91 (0.51-1.59) | .729 | |
| P-value (LR test) | Activation score† | .003 | .003 | ||
| Inhibition score‡ | .335 | .380 | |||
| Weighted average§ | Activation score | 0.69 (0.47-1.03) | .068 | 0.69 (0.45-1.04) | .076 |
| Inhibition score | 0.87 (0.73-1.02) | .089 | 0.85 (0.71-1.01) | .064 | |
| Predicted genetic ancestry . | Type of score . | Unadjusted model . | Model adjusting for top 5 PCs . | ||
|---|---|---|---|---|---|
| Odds ratio (95% CI) . | P* . | Odds ratio (95% CI) . | P* . | ||
| Latino all races | Activation score | 0.60 (0.49-0.72) | <.001 | 0.59 (0.49-0.71) | <.001 |
| Inhibition score | 0.82 (0.66-1.01) | .066 | 0.81 (0.64-1.01) | .057 | |
| Non-Latino White | Activation score | 1.02 (0.78-1.32) | .907 | 1.03 (0.78-1.35) | .842 |
| Inhibition score | 0.94 (0.69-1.29) | .705 | 0.91 (0.66-1.27) | .592 | |
| Non-Latino Asian | Activation score | 0.65 (0.42-1.00) | .051 | 0.63 (0.38-1.01) | .052 |
| Inhibition score | 0.98 (0.59-1.62) | .945 | 0.91 (0.51-1.59) | .729 | |
| P-value (LR test) | Activation score† | .003 | .003 | ||
| Inhibition score‡ | .335 | .380 | |||
| Weighted average§ | Activation score | 0.69 (0.47-1.03) | .068 | 0.69 (0.45-1.04) | .076 |
| Inhibition score | 0.87 (0.73-1.02) | .089 | 0.85 (0.71-1.01) | .064 | |
A total of 390 Latino, 160 non-Latino White, and 64 non-Latino Asian mother-child pairs were included. LR test, log-likelihood ratio test.
P value based on a Wald test. Odds ratio statistically significantly different from the null with P < .05.
LR test comparing the null model (ALL case/control status ∼ activation score + inhibition score + genetic ancestry) to the model with an interaction term between ancestry and activation score (ALL case/control status ∼ activation score + inhibition score + genetic ancestry + activation score × genetic ancestry).
LR test comparing the null model (ALL case/control status ∼ activation score + inhibition score + genetic ancestry) to the model with an interaction term between ancestry and inhibition score (ALL case/control status ∼ activation score + inhibition score + genetic ancestry + inhibition score × genetic ancestry).
The weighted average of odds ratio among Latino all races, non-Latino White, and non-Latino Asian subjects. Calculated with a random-effects meta-analysis model where the weights are the number of subjects in each predicted genetic ancestry group.