Activation/inhibition effect for different combinations of maternal KIR and offspring HLA genes
| Maternal KIR gene* . | Offspring HLA allele† . | Inhibition score‡ . | Activation score‡ . |
|---|---|---|---|
| KIR2DL1 | C2 | 1 | |
| KIR2DL2 | C1 | 1 | |
| KIR2DL3 | C1 | 1 | |
| KIR2DL2 | C2 | 0.5 | |
| KIR2DL3 | C2 | 0.5 | |
| KIR3DL1 | BW4*80I | 1 | |
| KIR3DL1 | BW4*80T | 0.5 | |
| KIR3DL1 | A*23:01 | 0.5 | |
| KIR3DL1 | A*24:02 | 0.5 | |
| KIR3DL1 | A*24:03 | 0.5 | |
| KIR3DL1 | A*25:01 | 0.5 | |
| KIR3DL1 | A*32:01 | 1 | |
| KIR2DS1 | C2 | 1 | |
| KIR2DS2 | C1 | 1 | |
| KIR2DS4 | C*02:02 | 1 | |
| KIR2DS4 | C*04:01 | 1 | |
| KIR2DS4 | C*05:01 | 1 | |
| KIR2DS4 | C*01:02 | 1 | |
| KIR2DS4 | C*14:02 | 1 | |
| KIR2DS4 | C*16:01 | 1 | |
| KIR2DS5 | C2 | 1 | |
| KIR3DS1 | BW4*80I | 1 |
| Maternal KIR gene* . | Offspring HLA allele† . | Inhibition score‡ . | Activation score‡ . |
|---|---|---|---|
| KIR2DL1 | C2 | 1 | |
| KIR2DL2 | C1 | 1 | |
| KIR2DL3 | C1 | 1 | |
| KIR2DL2 | C2 | 0.5 | |
| KIR2DL3 | C2 | 0.5 | |
| KIR3DL1 | BW4*80I | 1 | |
| KIR3DL1 | BW4*80T | 0.5 | |
| KIR3DL1 | A*23:01 | 0.5 | |
| KIR3DL1 | A*24:02 | 0.5 | |
| KIR3DL1 | A*24:03 | 0.5 | |
| KIR3DL1 | A*25:01 | 0.5 | |
| KIR3DL1 | A*32:01 | 1 | |
| KIR2DS1 | C2 | 1 | |
| KIR2DS2 | C1 | 1 | |
| KIR2DS4 | C*02:02 | 1 | |
| KIR2DS4 | C*04:01 | 1 | |
| KIR2DS4 | C*05:01 | 1 | |
| KIR2DS4 | C*01:02 | 1 | |
| KIR2DS4 | C*14:02 | 1 | |
| KIR2DS4 | C*16:01 | 1 | |
| KIR2DS5 | C2 | 1 | |
| KIR3DS1 | BW4*80I | 1 |
KIR imputed with KIR*Imp or directly genotyped (CCLS samples only).
HLA imputed with HIBAG by predicted genetic ancestry group or directly genotyped (CCLS samples only).
Inhibition/activation score = 1 if indicated as strong inhibition/activation in previous study; score = 0.5 if indicated as weak inhibition/activation in previous study.