Table 1. Characteristics of the 11... | American Society of Hematology

Table 1.

Characteristics of the 11 familial lymphoproliferative disorder cases with IGLV3-21 gene usage

Case	Age at diagnosis, y	Sex	IGHV	Subset 2	IGLV3-21	R110	Relatives with CLL (light chain isotype)
1	83	Female	IGHV4-4	No	Yes	Yes	Brother (kappa)
2	65	Female	IGHV3-21	Yes	Yes	Yes	Mother (unknown)
3	66	Female	IGHV1-18	No	Yes	Yes	Brother (kappa)
4	48	Male	IGHV3-48	No	Yes	No	NA*
5	49	Male	IGHV3-23	No	Yes	Yes	Brother (kappa); father (unknown)
6	64	Male	IGHV1-69	No	Yes	No	NA*
7	73	Male	IGHV3-21	Yes	Yes	Yes	Brother (kappa); daughter (kappa)
8	48	Male	Unknown	No	Yes	Yes	NA†
9	55	Male	IGHV3-15	No	Yes	No	NA*
10	65	Male	IGHV4-59	No	Yes	Yes	Cousin (kappa)
11	40	Female	IGHV3-66	No	Yes	Yes	Mother (kappa)

Case	Age at diagnosis, y	Sex	IGHV	Subset 2	IGLV3-21	R110	Relatives with CLL (light chain isotype)
1	83	Female	IGHV4-4	No	Yes	Yes	Brother (kappa)
2	65	Female	IGHV3-21	Yes	Yes	Yes	Mother (unknown)
3	66	Female	IGHV1-18	No	Yes	Yes	Brother (kappa)
4	48	Male	IGHV3-48	No	Yes	No	NA*
5	49	Male	IGHV3-23	No	Yes	Yes	Brother (kappa); father (unknown)
6	64	Male	IGHV1-69	No	Yes	No	NA*
7	73	Male	IGHV3-21	Yes	Yes	Yes	Brother (kappa); daughter (kappa)
8	48	Male	Unknown	No	Yes	Yes	NA†
9	55	Male	IGHV3-15	No	Yes	No	NA*
10	65	Male	IGHV4-59	No	Yes	Yes	Cousin (kappa)
11	40	Female	IGHV3-66	No	Yes	Yes	Mother (kappa)

NA, not applicable.

Cases 4, 6, and 9, absence of R110 mutation.

Case 8, relative with follicular lymphoma.