Characteristics of the study cohort of 508 patients with cytopenia
| . | Entire cohort . | Discovery cohort . | Validation cohort . |
|---|---|---|---|
| Number of patients | 508 | 340 | 168 |
| Age, median (IQR), y | 68 (57-75) | 69 (57-76) | 67 (56-73) |
| <50 | 90 (18%) | 62 (18%) | 28 (17%) |
| 50-74 | 293 (58%) | 186 (55%) | 107 (64%) |
| ≥75 | 125 (25%) | 92 (27%) | 33 (20%) |
| Sex, male/female | 288/220 | 195/145 | 93/75 |
| Diagnosis | |||
| ICUS | 181 (36%) | 117 (34%) | 64 (38%) |
| CCUS | 132 (26%) | 85 (25%) | 47 (28%) |
| MDS | 93 (18%) | 62 (18%) | 31 (18%) |
| CMML | 22 (4%) | 20 (6%) | 2 (1%) |
| AML | 37 (7%) | 26 (8%) | 11 (7%) |
| Other | 48 (8%) | 30 (9%) | 13 (8%) |
| One or more mutations present | 267 (53%) | 179 (53%) | 88 (52%) |
| Cytogenetics | |||
| Normal karyotype | 351 (69%) | 229 (67%) | 122 (73%) |
| Aberrant karyotype | 107 (21%) | 78 (23%) | 29 (17%) |
| Analysis not performed | 50 (10%) | 33 (10%) | 17 (10%) |
| Hemoglobin, median (IQR), mmol/L | 6.9 (5.8-8.0) | 6.8 (5.7-8.0) | 7.1 (6.0-8.0) |
| Platelet count, median (IQR), ×109/L | 118 (74-216) | 120 (74-213) | 114 (72-219) |
| Absolute neutrophil count, median (IQR), ×109/L | 2.2 (1.1-4.2) | 2.4 (1.1-4.7) | 1.8 (1.1-3.4) |
| . | Entire cohort . | Discovery cohort . | Validation cohort . |
|---|---|---|---|
| Number of patients | 508 | 340 | 168 |
| Age, median (IQR), y | 68 (57-75) | 69 (57-76) | 67 (56-73) |
| <50 | 90 (18%) | 62 (18%) | 28 (17%) |
| 50-74 | 293 (58%) | 186 (55%) | 107 (64%) |
| ≥75 | 125 (25%) | 92 (27%) | 33 (20%) |
| Sex, male/female | 288/220 | 195/145 | 93/75 |
| Diagnosis | |||
| ICUS | 181 (36%) | 117 (34%) | 64 (38%) |
| CCUS | 132 (26%) | 85 (25%) | 47 (28%) |
| MDS | 93 (18%) | 62 (18%) | 31 (18%) |
| CMML | 22 (4%) | 20 (6%) | 2 (1%) |
| AML | 37 (7%) | 26 (8%) | 11 (7%) |
| Other | 48 (8%) | 30 (9%) | 13 (8%) |
| One or more mutations present | 267 (53%) | 179 (53%) | 88 (52%) |
| Cytogenetics | |||
| Normal karyotype | 351 (69%) | 229 (67%) | 122 (73%) |
| Aberrant karyotype | 107 (21%) | 78 (23%) | 29 (17%) |
| Analysis not performed | 50 (10%) | 33 (10%) | 17 (10%) |
| Hemoglobin, median (IQR), mmol/L | 6.9 (5.8-8.0) | 6.8 (5.7-8.0) | 7.1 (6.0-8.0) |
| Platelet count, median (IQR), ×109/L | 118 (74-216) | 120 (74-213) | 114 (72-219) |
| Absolute neutrophil count, median (IQR), ×109/L | 2.2 (1.1-4.2) | 2.4 (1.1-4.7) | 1.8 (1.1-3.4) |