Laboratory and clinical characteristics of patients suspected of VITT in the development cohort
| Variable . | All (N = 47) . | VITT positive (n = 23) . | VITT negative (n = 20) . | ELISA false positive (n = 4) . | P* . |
|---|---|---|---|---|---|
| Sex | .350 | ||||
| Female | 19 | 11 | 6 | 2 | |
| Male | 28 | 12 | 14 | 2 | |
| Age, y | 70 (58-81) | 65 (52-75) | 74 (63-83) | 69 (50-84) | .017 |
| Days’ postvaccine | 10 (7-17) | 9 (8-14) | 12 (5-20) | 8 (7-15) | .912 |
| Platelet count (×109/L) | 85 (39-135) | 45 (30-65) | 130 (114-143) | 232 (209-255) | <.0001 |
| D-dimer (fold-change over ULN) | 33.8 (9.4-40) | 40 (30-70) | 14.4 (5.1-28.3) | <5× ULN in 3 patients | .006 |
| Thrombosis | 45 | 23 | 19 | 3 | .465 |
| Variable . | All (N = 47) . | VITT positive (n = 23) . | VITT negative (n = 20) . | ELISA false positive (n = 4) . | P* . |
|---|---|---|---|---|---|
| Sex | .350 | ||||
| Female | 19 | 11 | 6 | 2 | |
| Male | 28 | 12 | 14 | 2 | |
| Age, y | 70 (58-81) | 65 (52-75) | 74 (63-83) | 69 (50-84) | .017 |
| Days’ postvaccine | 10 (7-17) | 9 (8-14) | 12 (5-20) | 8 (7-15) | .912 |
| Platelet count (×109/L) | 85 (39-135) | 45 (30-65) | 130 (114-143) | 232 (209-255) | <.0001 |
| D-dimer (fold-change over ULN) | 33.8 (9.4-40) | 40 (30-70) | 14.4 (5.1-28.3) | <5× ULN in 3 patients | .006 |
| Thrombosis | 45 | 23 | 19 | 3 | .465 |
Continuous variables are expressed as median (interquartile range).
ULN, upper limit of normal.
Fisher’s exact test (categorical variables) or Mann-Whitney U test (continuous variables) between VITT-positive and VITT-negative groups. P < .05 are in bold.