AEs within the first 30 d after CAR T-cell infusion
| . | No. of patients . | |
|---|---|---|
| All grades . | Grade ≥3 . | |
| AEs | ||
| Fatigure | 1 (2.1) | 0 |
| Dyspnea | 4 (8.3) | 2 (4.2) |
| Nausea + anorexia | 22 (45.8) | 4 (8.3) |
| Diarrhea + constipation | 1 (2.1) | 0 |
| Myalgia | 2 (4.2) | 0 |
| Oral mucositis | 1 (2.1) | 0 |
| Infection | 6 (12.5) | 2 (4.2) |
| Fever | 44 (91.7) | 33 (68.8) |
| Hypotension | 8 (16.7) | 4 (8.3) |
| Hypoxia | 6 (12.5) | 4 (8.3) |
| Tachycardia | 3 (6.3) | 2 (4.2) |
| Capillary leak syndrome | 1 (2.1) | 1 (2.1) |
| CRS | 43 (89.6) | 9 (18.8) |
| Hematologic AEs | ||
| Neutropenia | 42 (87.5) | 34 (70.8) |
| Lymphocytopenia | 40 (83.3) | 35 (72.9) |
| Thrombocytopenia | 29 (60.4) | 16 (33.3) |
| Hypoglobinemia | 32 (66.7) | 22 (45.8) |
| Multisystem AEs | ||
| Gastrointestinal bleeding | 1 (2.1) | 1 (2.1) |
| Hemoptysis | 1 (2.1) | 1 (2.1) |
| Intracranial hemorrhage | 1 (2.1) | 1 (2.1) |
| Acute pancreatitis | 1 (2.1) | 1 (2.1) |
| Heart failure | 3 (6.3) | 3 (6.3) |
| Renal failure | 2 (4.2) | 2 (4.2) |
| Multiple organ and system failure | 1 (2.1) | 1 (2.1) |
| Laboratory abnormalities | ||
| ALT/AST elevation | 28 (58.3) | 11 (22.9) |
| Blood bilirubin elevation | 7 (14.6) | 5 (10.4) |
| Creatintine elevation | 8 (16.7) | 2 (4.2) |
| Electrolyte disturbance | 1 (2.1) | 1 (2.1) |
| Myocardial enzyme/BNP elevation | 14 (29.2) | 4 (8.3) |
| Fibrinogen decreased | 3 (6.3) | 3 (6.3) |
| NEs | ||
| Encephalopathy | 11 (22.9) | 4 (8.3) |
| Disturbance in attention | 6 (12.5) | 1 (2.1) |
| Cognitive disorder | 6 (12.5) | 2 (4.2) |
| Mental status changes | 1 (2.1) | 0 |
| Memory impairment | 2 (4.2) | 1 (2.1) |
| Lethargy | 4 (8.3) | 1 (2.1) |
| Depressed level of consciousness | 10 (20.8) | 3 (6.3) |
| Headache/dizziness | 7 (14.6) | 2 (4.2) |
| Tremor | 2 (4.2) | 1 (2.1) |
| Aphasia | 1 (2.1) | 1 (2.1) |
| Delirium | 8 (16.7) | 2 (4.2) |
| Motor dysfunction | 1 (2.1) | 1 (2.1) |
| Ataxia | 2 (4.2) | 0 |
| Seizure | 4 (8.3) | 4 (8.3) |
| Vision disorder | 3 (6.3) | 3 (6.3) |
| Tinnitus | 1 (2.1) | 1 (2.1) |
| . | No. of patients . | |
|---|---|---|
| All grades . | Grade ≥3 . | |
| AEs | ||
| Fatigure | 1 (2.1) | 0 |
| Dyspnea | 4 (8.3) | 2 (4.2) |
| Nausea + anorexia | 22 (45.8) | 4 (8.3) |
| Diarrhea + constipation | 1 (2.1) | 0 |
| Myalgia | 2 (4.2) | 0 |
| Oral mucositis | 1 (2.1) | 0 |
| Infection | 6 (12.5) | 2 (4.2) |
| Fever | 44 (91.7) | 33 (68.8) |
| Hypotension | 8 (16.7) | 4 (8.3) |
| Hypoxia | 6 (12.5) | 4 (8.3) |
| Tachycardia | 3 (6.3) | 2 (4.2) |
| Capillary leak syndrome | 1 (2.1) | 1 (2.1) |
| CRS | 43 (89.6) | 9 (18.8) |
| Hematologic AEs | ||
| Neutropenia | 42 (87.5) | 34 (70.8) |
| Lymphocytopenia | 40 (83.3) | 35 (72.9) |
| Thrombocytopenia | 29 (60.4) | 16 (33.3) |
| Hypoglobinemia | 32 (66.7) | 22 (45.8) |
| Multisystem AEs | ||
| Gastrointestinal bleeding | 1 (2.1) | 1 (2.1) |
| Hemoptysis | 1 (2.1) | 1 (2.1) |
| Intracranial hemorrhage | 1 (2.1) | 1 (2.1) |
| Acute pancreatitis | 1 (2.1) | 1 (2.1) |
| Heart failure | 3 (6.3) | 3 (6.3) |
| Renal failure | 2 (4.2) | 2 (4.2) |
| Multiple organ and system failure | 1 (2.1) | 1 (2.1) |
| Laboratory abnormalities | ||
| ALT/AST elevation | 28 (58.3) | 11 (22.9) |
| Blood bilirubin elevation | 7 (14.6) | 5 (10.4) |
| Creatintine elevation | 8 (16.7) | 2 (4.2) |
| Electrolyte disturbance | 1 (2.1) | 1 (2.1) |
| Myocardial enzyme/BNP elevation | 14 (29.2) | 4 (8.3) |
| Fibrinogen decreased | 3 (6.3) | 3 (6.3) |
| NEs | ||
| Encephalopathy | 11 (22.9) | 4 (8.3) |
| Disturbance in attention | 6 (12.5) | 1 (2.1) |
| Cognitive disorder | 6 (12.5) | 2 (4.2) |
| Mental status changes | 1 (2.1) | 0 |
| Memory impairment | 2 (4.2) | 1 (2.1) |
| Lethargy | 4 (8.3) | 1 (2.1) |
| Depressed level of consciousness | 10 (20.8) | 3 (6.3) |
| Headache/dizziness | 7 (14.6) | 2 (4.2) |
| Tremor | 2 (4.2) | 1 (2.1) |
| Aphasia | 1 (2.1) | 1 (2.1) |
| Delirium | 8 (16.7) | 2 (4.2) |
| Motor dysfunction | 1 (2.1) | 1 (2.1) |
| Ataxia | 2 (4.2) | 0 |
| Seizure | 4 (8.3) | 4 (8.3) |
| Vision disorder | 3 (6.3) | 3 (6.3) |
| Tinnitus | 1 (2.1) | 1 (2.1) |
Data are presented as n (%). AEs were captured for all treated patients within the first 30 d after CAR T-cell infusion.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BNP, brain natriuretic peptide.