Rates of aGVHD and cGVHD and complications after stem cell transplantation
| Variable . | CsA/MPA (n = 52), n (%) . | PT-Cy/CsA (n = 99), n (%) . | P value . |
|---|---|---|---|
| Nonsevere GVHD <180 d posttransplant | 15 (29) | 38 (38) | .26 |
| aGVHD | 34 (65) | 64 (65) | 1.00 |
| Maximum overall grade per patient* | |||
| Grade 1 | 5 (10) | 31 (31) | |
| Grade 2 | 21 (40) | 27 (27) | |
| Grade 3 | 6 (12) | 5 (5) | |
| Grade 4 | 2 (4) | 1 (1) | |
| cGVHD | 36 (69) | 49 (49) | .025 |
| Maximum overall grade per patient† | |||
| Limited | 9 (17) | 25 (25) | |
| Extensive | 27 (52) | 24 (24) | |
| CTC grade 3-5 AEs <6 mo posttransplant‡ | |||
| All events | 22 (42) | 60 (61) | .039 |
| Infections | 11 (21) | 41 (41) | .019 |
| Febrile neutropenia | 8 (15) | 25 (25) | .22 |
| Invasive pulmonary aspergillosis | 2 (4) | 4 (4) | 1.00 |
| Pulmonary infections other | — | 3 (3) | .55 |
| CMV disease | — | 1 (1) | 1.00 |
| Graft failure | 1 (2) | 1 (1) | 1.00 |
| Cardiac | 2 (4) | 3 (3) | 1.00 |
| Variable . | CsA/MPA (n = 52), n (%) . | PT-Cy/CsA (n = 99), n (%) . | P value . |
|---|---|---|---|
| Nonsevere GVHD <180 d posttransplant | 15 (29) | 38 (38) | .26 |
| aGVHD | 34 (65) | 64 (65) | 1.00 |
| Maximum overall grade per patient* | |||
| Grade 1 | 5 (10) | 31 (31) | |
| Grade 2 | 21 (40) | 27 (27) | |
| Grade 3 | 6 (12) | 5 (5) | |
| Grade 4 | 2 (4) | 1 (1) | |
| cGVHD | 36 (69) | 49 (49) | .025 |
| Maximum overall grade per patient† | |||
| Limited | 9 (17) | 25 (25) | |
| Extensive | 27 (52) | 24 (24) | |
| CTC grade 3-5 AEs <6 mo posttransplant‡ | |||
| All events | 22 (42) | 60 (61) | .039 |
| Infections | 11 (21) | 41 (41) | .019 |
| Febrile neutropenia | 8 (15) | 25 (25) | .22 |
| Invasive pulmonary aspergillosis | 2 (4) | 4 (4) | 1.00 |
| Pulmonary infections other | — | 3 (3) | .55 |
| CMV disease | — | 1 (1) | 1.00 |
| Graft failure | 1 (2) | 1 (1) | 1.00 |
| Cardiac | 2 (4) | 3 (3) | 1.00 |
CMV, cytomegalovirus; CTC, common toxicity criteria.
Severity of aGVHD according to the updated Glucksberg classification (supplemental Table 1).
Severity of cGVHD according to the Seattle criteria (supplemental Table 2).
The complete list of CTC grade 3 to 5 events <6 mo posttransplantation is available in supplemental Table 4.