Table 2. Treatment-emergent AEs AEs .... | American Society of Hematology

Table 2.

Treatment-emergent AEs

AEs	All treated patients (n = 159), n (%)
AEs	Any grade	Grade 3/4
Most common AEs*
Diarrhea	99 (62)	5 (3)
Nausea	68 (43)	2 (1)
Neutropenia	66 (42)	52 (33)
Arthralgia	53 (33)	2 (1)
Hypertension	25 (16)	9 (6)
Neutrophil count decreased	16 (10)	8 (5)
Other AEs of clinical interest
Atrial fibrillation	7 (4)	2 (1)
Major hemorrhage†	3 (2)	2 (1)
Laboratory safety parameters
Hematology
Neutrophils decreased	115 (72)	60 (38)
Platelets decreased	94 (59)	20 (13)
Hemoglobin decreased	31 (19)	0
Chemistry
Corrected calcium decreased	61 (38)	1 (1)
Potassium increased	39 (25)	4 (3)
Uric acid increased	34 (21)	34 (21)
Creatinine increased	27 (17)	0

AEs	All treated patients (n = 159), n (%)
AEs	Any grade	Grade 3/4
Most common AEs*
Diarrhea	99 (62)	5 (3)
Nausea	68 (43)	2 (1)
Neutropenia	66 (42)	52 (33)
Arthralgia	53 (33)	2 (1)
Hypertension	25 (16)	9 (6)
Neutrophil count decreased	16 (10)	8 (5)
Other AEs of clinical interest
Atrial fibrillation	7 (4)	2 (1)
Major hemorrhage†	3 (2)	2 (1)
Laboratory safety parameters
Hematology
Neutrophils decreased	115 (72)	60 (38)
Platelets decreased	94 (59)	20 (13)
Hemoglobin decreased	31 (19)	0
Chemistry
Corrected calcium decreased	61 (38)	1 (1)
Potassium increased	39 (25)	4 (3)
Uric acid increased	34 (21)	34 (21)
Creatinine increased	27 (17)	0

AEs of any grade occurring in ≥30% of patients or grade 3/4 occurring in ≥5% of patients.

Major hemorrhage was identified using the Standardized MedDRA Query for Hemorrhage, excluding laboratory terms.