Prevalence of select AEs by 6-mo intervals
| AE, n (%) . | 0-6 mo (n = 86), n (%) . | >6-12 mo (n = 68), n (%) . | >12-18 mo (n = 61), n (%) . | >18-24 mo (n = 53), n (%) . | >24-30 mo (n = 47), n (%) . | >30 mo (n = 40), n (%) . |
|---|---|---|---|---|---|---|
| Any infections | 45 (52.3) | 22 (32.4) | 14 (23.0) | 10 (18.9) | 7 (14.9) | 5 (12.5) |
| Grade ≥3 | 7 (8.1) | 4 (5.9) | 2 (3.3) | 2 (3.8) | 3 (6.4) | 1 (2.5) |
| Any neutropenia | 26 (30.2) | 20 (29.4) | 12 (19.7) | 4 (7.6) | 4 (8.5) | 3 (7.5) |
| Grade ≥3 | 7 (8.1) | 9 (13.2) | 2 (3.3) | 0 | 0 | 0 |
| Any thrombocytopenia | 18 (20.9) | 16 (23.5) | 6 (9.8) | 7 (13.2) | 6 (12.8) | 4 (10.0) |
| Grade ≥3 | 1 (1.2) | 3 (4.4) | 0 | 2 (3.8) | 0 | 0 |
| Any bleeding | 16 (18.6) | 8 (11.8) | 7 (11.5) | 6 (11.3) | 6 (12.8) | 4 (10.0) |
| Grade ≥3 | 1 (1.2) | 0 | 0 | 0 | 0 | 0 |
| Any diarrhea | 9 (10.5) | 4 (5.9) | 3 (4.9) | 1 (1.9) | 1 (2.1) | 0 |
| Grade ≥3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Any hypertension | 4 (4.7) | 7 (10.3) | 2 (3.3) | 2 (3.8) | 0 | 1 (2.5) |
| Grade ≥3 | 1 (1.2) | 2 (2.9) | 1 (1.6) | 0 | 0 | 0 |
| AE, n (%) . | 0-6 mo (n = 86), n (%) . | >6-12 mo (n = 68), n (%) . | >12-18 mo (n = 61), n (%) . | >18-24 mo (n = 53), n (%) . | >24-30 mo (n = 47), n (%) . | >30 mo (n = 40), n (%) . |
|---|---|---|---|---|---|---|
| Any infections | 45 (52.3) | 22 (32.4) | 14 (23.0) | 10 (18.9) | 7 (14.9) | 5 (12.5) |
| Grade ≥3 | 7 (8.1) | 4 (5.9) | 2 (3.3) | 2 (3.8) | 3 (6.4) | 1 (2.5) |
| Any neutropenia | 26 (30.2) | 20 (29.4) | 12 (19.7) | 4 (7.6) | 4 (8.5) | 3 (7.5) |
| Grade ≥3 | 7 (8.1) | 9 (13.2) | 2 (3.3) | 0 | 0 | 0 |
| Any thrombocytopenia | 18 (20.9) | 16 (23.5) | 6 (9.8) | 7 (13.2) | 6 (12.8) | 4 (10.0) |
| Grade ≥3 | 1 (1.2) | 3 (4.4) | 0 | 2 (3.8) | 0 | 0 |
| Any bleeding | 16 (18.6) | 8 (11.8) | 7 (11.5) | 6 (11.3) | 6 (12.8) | 4 (10.0) |
| Grade ≥3 | 1 (1.2) | 0 | 0 | 0 | 0 | 0 |
| Any diarrhea | 9 (10.5) | 4 (5.9) | 3 (4.9) | 1 (1.9) | 1 (2.1) | 0 |
| Grade ≥3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Any hypertension | 4 (4.7) | 7 (10.3) | 2 (3.3) | 2 (3.8) | 0 | 1 (2.5) |
| Grade ≥3 | 1 (1.2) | 2 (2.9) | 1 (1.6) | 0 | 0 | 0 |