Table 1. Multivariate analyses for OS,... | American Society of Hematology

Table 1.

Multivariate analyses for OS, EFS, and LFS in the pediatric (upper panel) and adult (lower panel) datasets

	OS			EFS			LFS
ELAM02 entire set	HR	95CI	P	HR	95CI	P	HR	95CI	P
ABCA3 gene expression (>1.20 AU)	1.93	1.18-3.14	.009	1.92	1.31-2.82	<.001	1.81	1.21-2.71	.004
Risk group^*	1.62	1.12-2.36	.011	1.32	0.98-1.76	.06	—	—	—
Age (>6 y)	2.27	1.25-4.13	.007	2.04	1.30-3.22	.002	1.99	1.24-3.22	.005
Leukocytes (>30 g/L)	2.02	1.24-3.29	.005	1.78	1.22-2.60	.003	1.53	1.02-2.29	.041
	OS			EFS			LFS
ALFA0701 entire set	HR	95CI	P	HR	95CI	P	HR	95CI	P
ABCA3 gene expression (>1.20 AU)	1.7	0.7-4.0	.20	2.6	1.3-6.5	.01	2.6	1.1-5.9	.03
CD33 expression (>90% blasts +)	0.5	0.3-1.0	.04	0.6	0.3-0.9	.03	0.5	0.3-1.0	.05
Normal karyotype	—	—	—	0.6	0.4-1.0	.06	—	—	—
ELN risk stratification	2.2	1.3-3.5	.002	—	—	—	—	—	—

	OS			EFS			LFS
ELAM02 entire set	HR	95CI	P	HR	95CI	P	HR	95CI	P
ABCA3 gene expression (>1.20 AU)	1.93	1.18-3.14	.009	1.92	1.31-2.82	<.001	1.81	1.21-2.71	.004
Risk group^*	1.62	1.12-2.36	.011	1.32	0.98-1.76	.06	—	—	—
Age (>6 y)	2.27	1.25-4.13	.007	2.04	1.30-3.22	.002	1.99	1.24-3.22	.005
Leukocytes (>30 g/L)	2.02	1.24-3.29	.005	1.78	1.22-2.60	.003	1.53	1.02-2.29	.041
	OS			EFS			LFS
ALFA0701 entire set	HR	95CI	P	HR	95CI	P	HR	95CI	P
ABCA3 gene expression (>1.20 AU)	1.7	0.7-4.0	.20	2.6	1.3-6.5	.01	2.6	1.1-5.9	.03
CD33 expression (>90% blasts +)	0.5	0.3-1.0	.04	0.6	0.3-0.9	.03	0.5	0.3-1.0	.05
Normal karyotype	—	—	—	0.6	0.4-1.0	.06	—	—	—
ELN risk stratification	2.2	1.3-3.5	.002	—	—	—	—	—	—

Cox proportional hazard models factoring variables with a P ≤ .10 in univariate analyses.

HR, hazard ratio; CI95, 95% confidence interval. --, no data.

Riskgroup values are defined according to the ELAM02 and ALFA0701 risk stratification.