Table 5.

Summary of GWAS results

Outcome, cohort, and genomeNumber of discovery variants*Number of discovery signals†Number of replicated signals‡
aGVHD§ 
 All donors 7 4 0 
 All recipients 155 9 0 
 10/10 HLA-matched sibling donors 28 7 0 
 10/10 HLA-matched sibling recipients 34 5 0 
 10/10 HLA-matched unrelated donors 8 3 0 
 10/10 HLA-matched unrelated recipients 13 8 0 
cGVHD 
 All donors 3 1 0 
 All recipients 5 3 0 
 10/10 HLA-matched sibling donors 0 0 0 
 10/10 HLA-matched sibling recipients 8 2 1 
 10/10 HLA-matched unrelated donors 2 1 0 
 10/10 HLA-matched unrelated recipients 2 2 0 
Relapse 
 All donors 1 1 0 
 All recipients 1 1 0 
 10/10 HLA-matched sibling donors 2 1 0 
 10/10 HLA-matched sibling recipients 3 2 0 
 10/10 HLA-matched unrelated donors 1 1 0 
 10/10 HLA-matched unrelated recipients 1 1 0 
Outcome, cohort, and genomeNumber of discovery variants*Number of discovery signals†Number of replicated signals‡
aGVHD§ 
 All donors 7 4 0 
 All recipients 155 9 0 
 10/10 HLA-matched sibling donors 28 7 0 
 10/10 HLA-matched sibling recipients 34 5 0 
 10/10 HLA-matched unrelated donors 8 3 0 
 10/10 HLA-matched unrelated recipients 13 8 0 
cGVHD 
 All donors 3 1 0 
 All recipients 5 3 0 
 10/10 HLA-matched sibling donors 0 0 0 
 10/10 HLA-matched sibling recipients 8 2 1 
 10/10 HLA-matched unrelated donors 2 1 0 
 10/10 HLA-matched unrelated recipients 2 2 0 
Relapse 
 All donors 1 1 0 
 All recipients 1 1 0 
 10/10 HLA-matched sibling donors 2 1 0 
 10/10 HLA-matched sibling recipients 3 2 0 
 10/10 HLA-matched unrelated donors 1 1 0 
 10/10 HLA-matched unrelated recipients 1 1 0 
*

P < 5 × 10−7.

†

Groups of variants with r2 > 0.7.

‡

Threshold P values corrected for the number of discovery signals.

§

Different subcategories of aGVHD associated with the same variant are counted only once.

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