Table 2. Summary of candidate variant... | American Society of Hematology

Table 2.

Summary of candidate variant results

Outcome, cohort, and genome	Number of discovery variants*	Number of discovery signals†	Number of replicated signals‡
aGVHD§
All donors	6	5	0
All recipients	7	6	0
10/10 HLA-matched sibling donors	10	6	0
10/10 HLA-matched sibling recipients	5	5	0
10/10 HLA-matched unrelated donors	5	3	0
10/10 HLA-matched unrelated recipients	12	9	1
cGVHD
All donors	0	0	0
All recipients	2	2	0
10/10 HLA-matched sibling donors	2	2	0
10/10 HLA-matched sibling recipients	1	1	0
10/10 HLA-matched unrelated donors	2	2	0
10/10 HLA-matched unrelated recipients	2	1	0
Relapse
All donors	3	3	0
All recipients	2	1	1
10/10 HLA-matched sibling donors	0	0	0
10/10 HLA-matched sibling recipients	4	3	0
10/10 HLA-matched unrelated donors	0	0	0
10/10 HLA-matched unrelated recipients	3	1	1

Outcome, cohort, and genome	Number of discovery variants*	Number of discovery signals†	Number of replicated signals‡
aGVHD§
All donors	6	5	0
All recipients	7	6	0
10/10 HLA-matched sibling donors	10	6	0
10/10 HLA-matched sibling recipients	5	5	0
10/10 HLA-matched unrelated donors	5	3	0
10/10 HLA-matched unrelated recipients	12	9	1
cGVHD
All donors	0	0	0
All recipients	2	2	0
10/10 HLA-matched sibling donors	2	2	0
10/10 HLA-matched sibling recipients	1	1	0
10/10 HLA-matched unrelated donors	2	2	0
10/10 HLA-matched unrelated recipients	2	1	0
Relapse
All donors	3	3	0
All recipients	2	1	1
10/10 HLA-matched sibling donors	0	0	0
10/10 HLA-matched sibling recipients	4	3	0
10/10 HLA-matched unrelated donors	0	0	0
10/10 HLA-matched unrelated recipients	3	1	1

P < .005; counts do not include different genetic models for the same outcome.

Groups of variants with r² > 0.7.

Threshold P values corrected for the number of discovery signals.

Different subcategories of aGVHD associated with the same variant are counted only once.