Univariable analysis of prognostic factors (other than MRD) in infants with KMT2A-r ALL
| Variable . | No. of patients . | 3-y and 5-y EFS rates, % (SE) . | P . |
|---|---|---|---|
| Sex | .046 | ||
| Male | 37 | 78.8 (7.1) | |
| Female | 38 | 55.3 (8.1) | |
| WBC × 109/L at diagnosis | .106 | ||
| <100 | 32 | 79.9 (7.4) | |
| 100 to < 300 | 16 | 60.0 (12.7) | |
| ≥300 | 27 | 53.8 (9.8) | |
| Age at diagnosis, days | .017 | ||
| 0-89 | 21 | 61.5 (11.5) | |
| 90-179 | 35 | 54.1 (8.5) | |
| 180-365 | 19 | 94.4 (5.4) | |
| KMT2A fusion | .416 | ||
| t(4;11)/KMT2A-AFF1 | 39 | 64.0 (7.7) | |
| t(9;11)/KMT2A-MLLT3 | 6 | 100 | |
| t(11;19)/KMT2A-MLLT1 | 15 | 60.0 (12.7) | |
| Other KMT2A-r | 15 | 63.6 (14.5) | |
| CNS status | .728 | ||
| CNS-1 | 42 | 69.0 (7.2) | |
| CNS-2 | 22 | 60.0 (11.0) | |
| CNS-3 | 10 | 63.5 (16.9) | |
| Unknown | 1 | — | |
| Prednisolone response | .071 | ||
| PGR | 48 | 73.9 (6.5) | |
| PPR | 27 | 52.1 (10.0) | |
| Bone marrow evaluation at the end of initial induction | .464 | ||
| M1 marrow | 64 | 66.6 (6.0) | |
| M2/M3 marrow | 5 | 53.3 (2.5) | |
| Unknown | 6 | — |
| Variable . | No. of patients . | 3-y and 5-y EFS rates, % (SE) . | P . |
|---|---|---|---|
| Sex | .046 | ||
| Male | 37 | 78.8 (7.1) | |
| Female | 38 | 55.3 (8.1) | |
| WBC × 109/L at diagnosis | .106 | ||
| <100 | 32 | 79.9 (7.4) | |
| 100 to < 300 | 16 | 60.0 (12.7) | |
| ≥300 | 27 | 53.8 (9.8) | |
| Age at diagnosis, days | .017 | ||
| 0-89 | 21 | 61.5 (11.5) | |
| 90-179 | 35 | 54.1 (8.5) | |
| 180-365 | 19 | 94.4 (5.4) | |
| KMT2A fusion | .416 | ||
| t(4;11)/KMT2A-AFF1 | 39 | 64.0 (7.7) | |
| t(9;11)/KMT2A-MLLT3 | 6 | 100 | |
| t(11;19)/KMT2A-MLLT1 | 15 | 60.0 (12.7) | |
| Other KMT2A-r | 15 | 63.6 (14.5) | |
| CNS status | .728 | ||
| CNS-1 | 42 | 69.0 (7.2) | |
| CNS-2 | 22 | 60.0 (11.0) | |
| CNS-3 | 10 | 63.5 (16.9) | |
| Unknown | 1 | — | |
| Prednisolone response | .071 | ||
| PGR | 48 | 73.9 (6.5) | |
| PPR | 27 | 52.1 (10.0) | |
| Bone marrow evaluation at the end of initial induction | .464 | ||
| M1 marrow | 64 | 66.6 (6.0) | |
| M2/M3 marrow | 5 | 53.3 (2.5) | |
| Unknown | 6 | — |