Patient characteristics of AML/MDS-EB with mutated TP53 (n = 230)
| . | AML (n = 186) . | MDS-EB (n = 44) . | AML/MDS-EB (n = 230) . | P . |
|---|---|---|---|---|
| Age, y | .820 | |||
| Median | 62 | 63 | 62 | |
| Range | 18-80 | 35-73 | 18-80 | |
| Sex, no. (%) | .736 | |||
| M | 111 (60) | 25 (57) | 136 (59) | |
| F | 75 (40) | 19 (43) | 94 (41) | |
| White blood cells at diagnosis, no. (%)* | ||||
| 100 | 183 (99) | 44 (100) | 227 (99) | 1.000 |
| 100 | 2 (1) | 0 (0) | 2 (1) | |
| Last treatment before first CR, no. (%) | ||||
| Refractory | 70 (38) | 10 (23) | 80 (35) | |
| Cycle I | 90 (48) | 29 (66) | 119 (52) | |
| Cycle II | 26 (14) | 5 (11) | 31 (13) | |
| Consolidation therapy, no. (%) | 1.000 | |||
| No allogeneic HSCT | 137 (74) | 33 (75) | 170 (74) | |
| Allogeneic HSCT | 49 (26) | 11 (25) | 60 (26) | |
| Cytogenetics, no. (%)† | ||||
| Monosomy 5 | 51 (28) | 11 (27) | 62 (28) | 1.000 |
| Deletion 5q | 78 (44) | 26 (63) | 104 (47) | |
| Monosomy 7 | 58 (32) | 14 (34) | 72 (33) | |
| Monosomy 17 | 71 (40) | 10 (24) | 81 (37) | |
| Abnormality 17p | 33 (18) | 6 (15) | 39 (18) | |
| Complex karyotype | 148 (83) | 37 (90) | 185 (84) | |
| Monosomal karyotype | 139 (78) | 35 (85) | 174 (79) |
| . | AML (n = 186) . | MDS-EB (n = 44) . | AML/MDS-EB (n = 230) . | P . |
|---|---|---|---|---|
| Age, y | .820 | |||
| Median | 62 | 63 | 62 | |
| Range | 18-80 | 35-73 | 18-80 | |
| Sex, no. (%) | .736 | |||
| M | 111 (60) | 25 (57) | 136 (59) | |
| F | 75 (40) | 19 (43) | 94 (41) | |
| White blood cells at diagnosis, no. (%)* | ||||
| 100 | 183 (99) | 44 (100) | 227 (99) | 1.000 |
| 100 | 2 (1) | 0 (0) | 2 (1) | |
| Last treatment before first CR, no. (%) | ||||
| Refractory | 70 (38) | 10 (23) | 80 (35) | |
| Cycle I | 90 (48) | 29 (66) | 119 (52) | |
| Cycle II | 26 (14) | 5 (11) | 31 (13) | |
| Consolidation therapy, no. (%) | 1.000 | |||
| No allogeneic HSCT | 137 (74) | 33 (75) | 170 (74) | |
| Allogeneic HSCT | 49 (26) | 11 (25) | 60 (26) | |
| Cytogenetics, no. (%)† | ||||
| Monosomy 5 | 51 (28) | 11 (27) | 62 (28) | 1.000 |
| Deletion 5q | 78 (44) | 26 (63) | 104 (47) | |
| Monosomy 7 | 58 (32) | 14 (34) | 72 (33) | |
| Monosomy 17 | 71 (40) | 10 (24) | 81 (37) | |
| Abnormality 17p | 33 (18) | 6 (15) | 39 (18) | |
| Complex karyotype | 148 (83) | 37 (90) | 185 (84) | |
| Monosomal karyotype | 139 (78) | 35 (85) | 174 (79) |